

Quantinuum is excited to announce the release of InQuanto™ v4.0, the latest version of our advanced quantum computational chemistry software. This update introduces new features and significant performance improvements, designed to help both industry and academic researchers accelerate their computational chemistry work.
If you're new to InQuanto or want to learn more about how to use it, we encourage you to explore our documentation.
InQuanto v4.0 is being released alongside Quantinuum Nexus, our cloud-based platform for quantum software. Users with Nexus access can leverage the `inquanto-nexus` extension to, for example, take advantage of multiple available backends and seamless cloud storage.
In addition, InQuanto v4.0 introduces enhancements that allow users to run larger chemical simulations on quantum computers. Systems can be easily imported from classical codes using the widely supported FCIDUMP file format. These fermionic representations are then efficiently mapped to qubit representations, benefiting from performance improvements in InQuanto operators. For systems too large for quantum hardware experiments, users can now utilize the new `inquanto-cutensornet` extension to run simulations via tensor networks.
These updates enable users to compile and execute larger quantum circuits with greater ease, while accessing powerful compute resources through Nexus.
InQuanto v4.0 is fully integrated with Quantinuum Nexus via the `inquanto-nexus` extension. This integration allows users to easily run experiments across a range of quantum backends, from simulators to hardware, and access results stored in Nexus cloud storage.
Results can be annotated for better searchability and seamlessly shared with others. Nexus also offers the Nexus Lab, which provides a preconfigured Jupyter environment for compiling circuits and executing jobs. The Lab is set up with InQuanto v4.0 and a full suite of related software, enabling users to get started quickly.
The `inquanto.mappings` submodule has received a significant performance enhancement in InQuanto v4.0. By integrating a set of operator classes written in C++, the team has increased the performance of the module past that of other open-source packages’ equivalent methods.
Like any other Python package, InQuanto can benefit from delegating tasks with high computational overhead to compiled languages such as C++. This prescription has been applied to the qubit encoding functions of the `inquanto.mappings` submodule, in which fermionic operators are mapped to their qubit operator equivalents. One such qubit encoding scheme is the Jordan-Wigner (JW) transformation. With respect to JW encoding as a benchmarking task, the integration of C++ operator classes in InQuanto v4.0 has yielded an execution time speed-up of two and a half times that of open-source competitors (Figure 1).

This is a substantial increase in performance that all users will benefit from. InQuanto users will still interact with the familiar Python classes such as `FermionOperator` and `QubitOperator` in v4.0. However, when the `mappings` module is called, the Python operator objects are converted to C++ equivalents and vice versa before and after the qubit encoding procedure (Figure 2). With future total integration of C++ operator classes, we can remove the conversion step and push the performance of the `mappings` module further. Tests, once again using the JW mappings scheme, show a 40 times execution time speed-up as compared to open-source competitors (Figure 1).

Efficient classical pre-processing implementations such as this are a crucial step on the path to quantum advantage. As the number of physical qubits available on quantum computers increases, so will the size and complexity of the physical systems that can be simulated. To support this hardware upscaling, computational bottlenecks including those associated with the classical manipulation of operator objects must be alleviated. Aside from keeping pace with hardware advancements, it is important to enlarge the tractable system size in situations that do not involve quantum circuit execution, such as tensor network circuit simulation and resource estimation.
Users with access to GPU capabilities can now take advantage of tensor networks to accelerate simulations in InQuanto v4.0. This is made possible by the `inquanto-cutensornet` extension, which interfaces InQuanto with the NVIDIA® cuTensorNet library. The `inquanto-cutensornet` extension leverages the `pytket-cutensornet` library, which facilitates the conversion of `pytket` circuits into tensor networks to be evaluated using the NVIDIA® cuTensorNet library. This extension increases the size limit of circuits that can be simulated for chemistry applications. Future work will seek to integrate this functionality with our Nexus platform, allowing InQuanto users to employ the extension without requiring access to their own local GPU resources.
Here we demonstrate the use of the `CuTensorNetProtocol` passed to a VQE experiment. For the sake of brevity, we use the `get_system` method of `inquanto.express` to swiftly define the system, in this case H2 using the STO-3G basis-set.
from inquanto.algorithms import AlgorithmVQE
from inquanto.ansatzes import FermionSpaceAnsatzUCCD
from inquanto.computables import ExpectationValue, ExpectationValueDerivative
from inquanto.express import get_system
from inquanto.mappings import QubitMappingJordanWigner
from inquanto.minimizers import MinimizerScipy
from inquanto.extensions.cutensornet import CuTensorNetProtocol
fermion_hamiltonian, space, state = get_system("h2_sto3g.h5")
qubit_hamiltonian = fermion_hamiltonian.qubit_encode()
ansatz = FermionSpaceAnsatzUCCD(space, state, QubitMappingJordanWigner())
expectation_value = ExpectationValue(ansatz, qubit_hamiltonian)
gradient_expression = ExpectationValueDerivative(
ansatz, qubit_hamiltonian, ansatz.free_symbols_ordered()
)
protocol_tn = CuTensorNetProtocol()
vqe_tn = (
AlgorithmVQE(
objective_expression=expectation_value,
gradient_expression=gradient_expression,
minimizer=MinimizerScipy(),
initial_parameters=ansatz.state_symbols.construct_zeros(),
)
.build(protocol_objective=protocol_tn, protocol_gradient=protocol_tn)
.run()
)
print(vqe_tn.generate_report()["final_value"])
# -1.136846575472054
The inherently modular design of InQuanto allows for the seamless integration of new extensions and functionality. For instance, a user can simply modify existing code using `SparseStatevectorProtocol` to enable GPU acceleration through `inquanto-cutensornet`. It is worth noting that the extension is also compatible with shot-based simulation via the `CuTensorNetShotsBackend` provided by `pytket-cutensornet`.
“Hybrid quantum-classical supercomputing is accelerating quantum computational chemistry research,” said Tim Costa, Senior Director at NVIDIA®. “With Quantinuum’s InQuanto v4.0 platform and NVIDIA’s cuQuantum SDK, InQuanto users now have access to unique tensor-network-based methods, enabling large-scale and high-precision quantum chemistry simulations.”
As demonstrated by our `inquanto-pyscf` extension, we want InQuanto to easily interface with classical codes. In InQuanto v4.0, we have clarified integration with other classical codes such as Gaussian and Psi4. All that is required is an FCIDUMP file, which is a common output file for classical codes. An FCIDUMP file encodes all the one and two electron integrals required to set up a CI Hamiltonian. Users can bring their system from classical codes by passing an FCIDUMP file to the `FCIDumpRestricted` class and calling the `to_ChemistryRestrictedIntegralOperator` method or its unrestricted counterpart, depending on how they wish to treat spin. The resulting InQuanto operator object can be used within their workflow as they usually would.
Users can experiment with TKET’s latest circuit compilation tools in a straightforward manner with InQuanto v4.0. Circuit compilation now only occurs within the `inquanto.protocols` module. This allows users to define which optimization passes to run before and/or after the backend specific defaults, all in one line of code. Circuit compilation is a crucial step in all InQuanto workflows. As such, this structural change allows us to cleanly integrate new functionality through extensions such as `inquanto-nexus` and `inquanto-cutensornet`. Looking forward, beyond InQuanto v4.0, this change is a positive step towards bringing quantum error correction to InQuanto.
InQuanto v4.0 pushes the size of the chemical systems that a user can simulate on quantum computers. Users can import larger, carefully constructed systems from classical codes and encode them to optimized quantum circuits. They can then evaluate these circuits on quantum backends with `inquanto-nexus` or execute them as tensor networks using `inquanto-cutensornet`. We look forward to seeing how our users leverage InQuanto v4.0 to demonstrate the increasing power of quantum computational chemistry. If you are curious about InQuanto and want to read further, our initial release blogpost is very informative or visit the InQuanto website.
If you are interested in trying InQuanto, please request access or a demo at inquanto@quantinuum.com
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.

We’re pleased to introduce Helios, a technological marvel redefining the possible.
Building on its predecessor H2, which has already breached quantum advantage, Helios nearly doubles the qubit count and surpasses H2’s industry-leading fidelity, pushing further into the quantum advantage regime than any system before it. With unprecedented capability across its full stack, Helios is the most powerful quantum computer in the world.
“Helios is a true marvel—a seamless fusion of hardware and software, creating a platform for discovery unlike any other.”
Dr. Rajeeb Hazra, CEO
Helios’ groundbreaking design and advanced software stack bring quantum programming closer than ever to the ease and flexibility of classical computing—positioning Helios to accelerate commercial adoption. Even before its public debut, Helios had already demonstrated its capabilities as the world’s first enterprise-grade quantum computer. During a two-month early access program, select partners including SoftBank Corp. and JPMorgan Chase conducted commercially relevant research. We also leveraged Helios to perform large-scale simulations in high-temperature superconductivity and quantum magnetism—both with clear pathways to real-world industry applications.
Helios is now available to all customers through our cloud service and on-premise offering, including an option to integrate with NVIDIA GB200 for applications targeting specific end markets.
“You would need to harvest every star in the universe to power a classical machine that could do the same calculations we did with Helios."
Dr. Anthony Ransford, Helios Lead Architect

As we detailed in a benchmarking paper, Helios sets a new standard for quantum computing performance with the highest fidelity ever released to the market. It features 98 fully connected physical qubits with single-qubit gate fidelity of 99.9975% and two-qubit gate fidelity of 99.921% across all qubit pairs—making it the most accurate commercial quantum computer in the world.
Our fidelity shines in system-level benchmarks, such as Random Circuit Sampling (RCS), famously used by Google to demonstrate quantum supremacy when it performed an RCS task that would take a classical computer “10 septillion years” to replicate. Now, RCS serves as both a benchmark and the minimum standard for serious competitors in the market. Frequently missed in this conversation, however, is the importance of fidelity, or accuracy. That's why, when benchmarking Helios using RCS, we report the fidelity achieved by Helios on circuits of varying complexity (with complexity quantified by power requirements for classical simulation).
Our results show a classical supercomputer would require more power than the Sun—or, in fact, the combined power of all stars in the visible universe—to complete the same task in the same amount of time. In contrast, Helios achieved it using roughly the power of a single data center rack.
Like its predecessors, H1 and H2, Helios is designed to improve fidelity and overall system performance over time while sustaining competitive leadership through the launch of its successor.

"When I first saw the rotatable ion storage ring with a junction and gating legs sketched on a napkin, I loved the idea for its simplicity and efficiency. Seeing it finally realized after all of the team’s hard work has been truly incredible."
Dr. John Gaebler, Fellow and Chief Scientist, Quantinuum
The Helios ion trap uses tiny currents to generate electromagnetic fields that hold single atomic ions (qubits) hovering above the trap for computation. We introduced a first-of-its-kind “junction”, which acts like a traffic intersection for qubits, enabling efficient routing and improved reliability. This is not only the first commercial implementation of this engineering triumph but it also allows our QCCD (Quantum Charged Coupled Device) architecture to scale, with future systems featuring hundreds of junctions arranged like a city street grid.

Whereas predecessor systems routed qubits using “physical swaps,” requiring sequential sorting, cooling, and gating that prevented parallel operations, the Helios QPU instead resembles a classical architecture with dedicated memory, cache, and computational zones. Like a spinning hard drive, the Helios QPU rotates qubits through ring storage (memory), passes them through the junction into the cache, moves them to logic zones for gating, and moves them to the leg storage while the next batch is processed. Sorting can now be done in parallel with cooling operations, resulting in a processor that is faster and less error prone. This parallelism will become a hallmark of Quantinuum’s future generations, enabling faster operating speeds.
Quantinuum’s QCCD provides full all-to-all connectivity, giving the Helios QPU significant advantages over “fixed qubit” architectures, such as those used in superconducting systems. Its ability to physically move qubits around and entangle any qubit with any other qubit enables algorithms and error-correcting codes that are functionally impossible for fixed qubit architectures.

We made another “tiny” but significant change: we switched our qubits from ytterbium to barium. Whereas ytterbium largely relied on ultraviolet lasers that are expensive and hard on other components, barium can be manipulated with lasers in the visible part of the spectrum, where mature industrial technology exists, providing a more affordable, reliable and scalable commercial solution.
Barium also naturally allows the quantum computer to detect and remove a certain type of error, known as leakage, at the atomic level. By addressing this error directly, programmers can enhance the performance of their computation.
As announced earlier this year, Helios launched with a completely new stack equipped with a new software environment that makes quantum programming feel as intuitive as classical development.
Our new stack also features a real-time engine that massively improves our capability. With a real-time control system, we are evolving from static, pre-planned circuits to dynamic quantum programs that respond to results on the fly. We can now, for the first time on a quantum computer, interleave GPU-accelerated classical and quantum computations in a single program.
Our real-time engine also means we have dynamic transport – routing qubits as the moment demands reduces time to solution and diminishes the impact of memory errors.

Programmers can now use our new quantum programming language, Guppy, to write dynamic circuits that were previously impossible. By combining Guppy with our real-time engine, developers can leverage arbitrary control flow driven by quantum measurements, as well as full classical computation—including loops, higher-order functions, early exits, and dynamic qubit allocation. Far from being mere conveniences, these capabilities are essential stepping stones toward achieving fault-tolerant quantum computing at scale—putting us decisively ahead of the competition.
Fully compatible with industry standards like QIR and tools such as NVIDIA CUDA-Q, Helios bridges classical and quantum computing more seamlessly than ever, making hybrid quantum-classical development simple, natural, and accessible, and establishing Helios as the most programmable, general-purpose quantum computer ever built.
While everyone else is promising fault-tolerance, we’re delivering it. We are the only company to demonstrate a fully universal fault-tolerant gate set, we’ve demonstrated more codes than anyone else, and our logical fidelities are the best in class.
Now, with 98 physical qubits, we’ve been able to make 94 logical qubits, fully entangled in one of the largest GHZ states ever recorded. We did this with better than break-even fidelity, meaning they outperform physical qubits running the same algorithm. Built on our Iceberg code, published last year in Nature Physics, these logical qubits achieve the industry’s highest encoding efficiency, needing only two ancilla qubits per code block, or roughly a 1:1 physical-to-logical qubit ratio.
With 50 error-detected logical qubits, Helios achieved better than break-even performance, running the largest encoded simulation of quantum magnetism to date—an exceptional example of how users can leverage efficient encodings. This range and flexibility let users tailor the encoding rate to their application: fewer logical qubits deliver higher fidelity for less complex tasks, while larger sets enable more complex simulations.
Helios also produced 48 fully error-corrected logical qubits at a remarkable 2:1 encoding rate, a ratio thought impossible just a few years ago. This super high encoding rate stands in stark contrast to other notable demonstrations from industry peers. For example, the demonstration linked in the previous sentence would need a whopping 4800 qubits to make 48 logical qubits. Our 2:1 encoding rate was achieved through a clever technique called code concatenation, a breakthrough that supports single-shot error correction, transversal logic, and full parallelization—all at 99.99% state preparation and measurement fidelity.
To extend this performance at scale, all future Quantinuum systems—starting with Helios—will integrate real-time decoding using NVIDIA Grace Hopper GPUs, treating decoding as a dynamic computational process rather than a static lookup. Errors can be corrected as computations run without slowing the logical clock rate. Combined with Guppy, NVIDIA CUDA-Q, and NVQLink, this infrastructure forms the foundation for fault-tolerant, real-time quantum computation, delivering immediate quantum advantage in the near term and a clear path to scalable error-corrected computing.
We remain the only company to perform a fully universal fault-tolerant gate set, with more error-correcting codes and higher logical fidelities than any other company.
Helios is ready to drive practical, commercial quantum applications across industries. Its unprecedented fidelity, scalability, and programmability give users the tools to tackle problems that were previously out of reach. This is just the beginning, and we look forward to seeing what users and companies will achieve with it.
Quantinuum’s real world experiment, on the world’s most powerful quantum computer, is the largest of its kind— so large that no amount of classical computing could match it

In 1911, a student working under famed physicist Heike Kamerlingh Onnes made a discovery that would rewire our understanding of electricity. The student was studying the electrical resistance of wires, a seemingly simple question that held secrets destined to surprise the world.
Kamerlingh Onnes had recently succeeded in liquefying helium, a feat so impressive it earned him the Nobel Prize in Physics two years later. With this breakthrough, scientists could now immerse other materials in a cold bath of liquid Helium, cooling things to unprecedented temperatures and observing their behavior.
Many theories existed about what would happen to a wire at such low temperatures. Lord Kelvin predicted that electrons would freeze in place, making the resistance infinite and stopping the conduction of electricity. Others expected resistance to decrease linearly with temperature—a hypothesis that led to thermometer designs still in use today.
When the student cooled a mercury wire to 3.6 degrees above absolute zero, he found something remarkable: the electrical resistivity suddenly vanished.
Onnes quickly devised an ingenious experiment: as a diligent researcher, he knew that he needed to validate these surprising findings. He took a closed loop of wire, set a current running through it, and watched as it flowed endlessly without fading—a type of perpetual motion that seemed to defy everything we know about physics. And so, superconductivity was born.
More than a century later, all known superconductors still require extreme conditions like brutal cold or high pressure. If we could instead design a material that superconducts at room temperature, and under normal conditions, our world would be profoundly reshaped. “Room temperature superconductivity”, as it is generally called, would enable a raft of technological breakthroughs from affordable MRI machines to nearly lossless power grids.
Designing such a material means answering many open questions, and scientists are pursuing diverse strategies to find answers. One promising approach is light-induced superconductivity. In one astonishing study, researchers at the Max Planck Institute in Hamburg used light to entice a material that normally superconducts at roughly -180 °C to superconduct at room temperature - but only for a few picoseconds. This effect raised new questions: how does light achieve something that scientists have been grappling with for decades? What is the microscopic mechanism behind this phenomenon? Could understanding it unlock practical room-temperature superconductors?
Physics is a surprisingly profound field when you stop to think about it. At its core lies the idea that nature speaks the language of mathematics—and that by discovering the right equations, we can reveal her secrets. As bold as that sounds, history has proven it true time and again. Whenever we peek behind the veil; mathematics is there.
To understand a phenomena like superconductivity, physicists first need a mathematical model, or a set of equations that describe how it works. With the right model, they can predict and even design new superconductors that operate under more practical conditions. This is a key frontier in the search for room temperature superconductors, one of science’s holy grails.
Since the discovery of superconductivity, a lot of work has gone into finding this right model – one that can act as a sort of ‘Rosetta stone’ for harnessing this phenomenon. One of the best bets for describing high temperature superconductors like the one in the Hamburg study is called the “non-equilibrium Fermi-Hubbard” model, which describes how electrons interact and move in a crystal.
A surprising element of models that describe superconductivity is the prediction that electrons ‘pair up’ when the material becomes superconducting, dancing around in a waltz, two at a time. These pairs are referred to as “cooper pairs” after the famous physicist Leon Cooper. Now, scientists studying superconductors look for “pairing correlations”, a key signature of superconductivity.
Even armed with the Fermi-Hubbard model, light-induced superconductivity has been very difficult to study. The world’s most powerful supercomputers can only handle very small versions, limiting their utility. Even quantum platforms, like analog simulators, limit researchers to observing ‘average’ quantities and obscuring the microscopic details that are crucial for unravelling this mystery.
Light-induced superconductivity has proved challenging to study with quantum computers as well, as doing so requires low error rates, many qubits, and extreme flexibility to measure the fickle symptoms of superconductivity.
That was, until now: Quantinuum’s Helios is one of the first machines in the world able to handle the complexity of the non-equilibrium Fermi-Hibbard model at scales previously out of reach.
Before Helios, we were limited to small explorations of this model, stalling research on this critical frontier. Now, with Helios, we have a quantum computer uniquely suited for this problem. With a novel fermionic encoding and using up to 90 qubits (72 system qubits plus 18 ancilla), Helios can simulate the dynamics of a 6×6 lattice — a system so large that its full quantum state spans over 2^72 dimensions.

Using Helios to study a system like this offers researchers a sort of “qubit-based laboratory.” Capable of handling complex quantum mechanical effects better than classical computers, Helios allows researchers to thoroughly explore phenomena like this without wasting expensive laboratory time and materials, or spending lots of money and energy running it on a supercomputer.
Our qubit-based laboratory is a dream come true for several reasons. First, it allows arbitrary state preparation – preparing states far from equilibrium, a challenging task for classical computers. Second, it allows for meaningfully long ‘dynamical simulation’ – seeing how the state evolves in time as entanglement spreads and complexity increases. This is notoriously difficult for classical computers, in part due to their difficulty with handling distinctly quantum phenomena like entanglement. Finally, it allows for flexible measurements and experimental parameters – you can measure any observable, including critical “off-diagonal” observables that carry the signature of superconductivity, and simulate any system, such as those with laser pulses or electric fields.
This last point is the most significant. While analog quantum simulators, like cold atom systems, can take snapshots of atom positions or measure densities, they struggle with off-diagonal observables—the very ones that signal the formation of Cooper pairs in superconductors.
In our work, we've simulated three different regimes of the Fermi-Hubbard model and successfully measured non-zero superconducting pairing correlations — a first for any quantum computing platform.
We began by preparing a low-energy state of the model at half-filling — a standard benchmark for testing quantum simulations. Then, using simulated laser pulses or electric fields, we perturbed the system and observed how it responded.
After these perturbations, we measured a notable increase in the so-called “eta” pairing correlations, a mathematical signature of superconducting behavior. These results prove that our computers can help us understand light-induced superconductivity, such as the results from the Max Planck researchers. However, unlike those physical experiments, Helios offers a new level of control and insight. By tuning every aspect of the simulation — from pulse shape, to field strength, to lattice geometry — researchers can explore scenarios that are completely inaccessible to real materials or analog simulators.
Why does any of this matter? If we could predict which materials will become superconducting — and at what temperature, field, or current — it would transform how we search for new superconductors. Instead of trial-and-error in the lab, scientists could design and test new materials digitally first, saving huge amounts of time and money.
In the long run, Helios and its successors will become essential tools for materials science — not just confirming theories but generating new ones. And perhaps, one day, they’ll help us crack the code behind room-temperature superconductors.
Until then, the quantum revolution continues, one entangled pair at a time.
Typically, Quantum Error Detection (QED) is viewed as a short-term solution—a non-scalable, stop-gap until full fault tolerance is achieved at scale.
That’s just changed, thanks to a serendipitous discovery made by our team. Now, QED can be used in a much wider context than previously thought. Our team made this discovery while studying the contact process, which describes things like how diseases spread or how water permeates porous materials. In particular, our team was studying the quantum contact process (QCP), a problem they had tackled before, which helps physicists understand things like phase transitions. In the process (pun intended), they came across what senior advanced physicist, Eli Chertkov, described as “a surprising result.”
While examining the problem, the team realized that they could convert detected errors due to noisy hardware into random resets, a key part of the QCP, thus avoiding the exponentially costly overhead of post-selection normally expected in QED.
To understand this better, the team developed a new protocol in which the encoded, or logical, quantum circuit adapts to the noise generated by the quantum computer. They quickly realized that this method could be used to explore other classes of random circuits similar to the ones they were already studying.
The team put it all together on System Model H2 to run a complex simulation, and were surprised to find that they were able to achieve near break-even results, where the logically encoded circuit performed as well as its physical analog, thanks to their clever application of QED. Ultimately, this new protocol will allow QED codes to be used in a scalable way, saving considerable computational resources compared to full quantum error correction (QEC).
Researchers at the crossroads of quantum information, quantum simulation, and many-body physics will take interest in this protocol and use it as a springboard for inventing new use cases for QED.
Stay tuned for more, our team always has new tricks up their sleeves.
Learn mode about System Model H2 with this video: