GenQAI: A New Era at the Quantum-AI Frontier
At the heart of quantum computing’s promise lies the ability to solve problems that are fundamentally out of reach for classical computers. One of the most powerful ways to unlock that promise is through a novel approach we call Generative Quantum AI, or GenQAI. A key element of this approach is the Generative Quantum Eigensolver (GQE).
GenQAI is based on a simple but powerful idea: combine the unique capabilities of quantum hardware with the flexibility and intelligence of AI. By using quantum systems to generate data, and then using AI to learn from and guide the generation of more data, we can create a powerful feedback loop that enables breakthroughs in diverse fields.
Unlike classical systems, our quantum processing unit (QPU) produces data that is extremely difficult, if not impossible, to generate classically. That gives us a unique edge: we’re not just feeding an AI more text from the internet; we’re giving it new and valuable data that can’t be obtained anywhere else.
The Search for Ground State Energy
One of the most compelling challenges in quantum chemistry and materials science is computing the properties of a molecule’s ground state. For any given molecule or material, the ground state is its lowest energy configuration. Understanding this state is essential for understanding molecular behavior and designing new drugs or materials.
The problem is that accurately computing this state for anything but the simplest systems is incredibly complicated. You cannot even do it by brute force—testing every possible state and measuring its energy—because the number of quantum states grows as a double-exponential, making this an ineffective solution. This illustrates the need for an intelligent way to search for the ground state energy and other molecular properties.
That’s where GQE comes in. GQE is a methodology that uses data from our quantum computers to train a transformer. The transformer then proposes promising trial quantum circuits; ones likely to prepare states with low energy. You can think of it as an AI-guided search engine for ground states. The novelty is in how our transformer is trained from scratch using data generated on our hardware.
Here's how it works:
- We start with a batch of trial quantum circuits, which are run on our QPU.
- Each circuit prepares a quantum state, and we measure the energy of that state with respect to the Hamiltonian for each one.
- Those measurements are then fed back into a transformer model (the same architecture behind models like GPT-2) to improve its outputs.
- The transformer generates a new distribution of circuits, biased toward ones that are more likely to find lower energy states.
- We sample a new batch from the distribution, run them on the QPU, and repeat.
- The system learns over time, narrowing in on the true ground state.
To test our system, we tackled a benchmark problem: finding the ground state energy of the hydrogen molecule (H₂). This is a problem with a known solution, which allows us to verify that our setup works as intended. As a result, our GQE system successfully found the ground state to within chemical accuracy.
To our knowledge, we’re the first to solve this problem using a combination of a QPU and a transformer, marking the beginning of a new era in computational chemistry.
The Future of Quantum Chemistry
The idea of using a generative model guided by quantum measurements can be extended to a whole class of problems—from combinatorial optimization to materials discovery, and potentially, even drug design.
By combining the power of quantum computing and AI we can unlock their unified full power. Our quantum processors can generate rich data that was previously unobtainable. Then, an AI can learn from that data. Together, they can tackle problems neither could solve alone.
This is just the beginning. We’re already looking at applying GQE to more complex molecules—ones that can’t currently be solved with existing methods, and we’re exploring how this methodology could be extended to real-world use cases. This opens many new doors in chemistry, and we are excited to see what comes next.
About Quantinuum
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.
If we are to create ‘next-gen’ AI that takes full advantage of the power of quantum computers, we need to start with quantum native transformers. Today we announce yet again that Quantinuum continues to lead by demonstrating concrete progress — advancing from theoretical models to real quantum deployment.
The future of AI won't be built on yesterday’s tech. If we're serious about creating next-generation AI that unlocks the full promise of quantum computing, then we must build quantum-native models—designed for quantum, from the ground up.
Around this time last year, we introduced Quixer, a state-of-the-art quantum-native transformer. Today, we’re thrilled to announce a major milestone: one year on, Quixer is now running natively on quantum hardware.
Why this matters: Quantum AI, born native
This marks a turning point for the industry: realizing quantum-native AI opens a world of possibilities.
Classical transformers revolutionized AI. They power everything from ChatGPT to real-time translation, computer vision, drug discovery, and algorithmic trading. Now, Quixer sets the stage for a similar leap — but for quantum-native computation. Because quantum computers differ fundamentally from classical computers, we expect a whole new host of valuable applications to emerge.
Achieving that future requires models that are efficient, scalable, and actually run on today’s quantum hardware.
That’s what we’ve built.
What makes Quixer different?
Until Quixer, quantum transformers were the result of a brute force “copy-paste” approach: taking the math from a classical model and putting it onto a quantum circuit. However, this approach does not account for the considerable differences between quantum and classical architectures, leading to substantial resource requirements.
Quixer is different: it’s not a translation – it's an innovation.
With Quixer, our team introduced an explicitly quantum transformer, built from the ground up using quantum algorithmic primitives. Because Quixer is tailored for quantum circuits, it's more resource efficient than most competing approaches.
As quantum computing advances toward fault tolerance, Quixer is built to scale with it.
What’s next for Quixer?
We’ve already deployed Quixer on real-world data: genomic sequence analysis, a high-impact classification task in biotech. We're happy to report that its performance is already approaching that of classical models, even in this first implementation.
This is just the beginning.
Looking ahead, we’ll explore using Quixer anywhere classical transformers have proven to be useful; such as language modeling, image classification, quantum chemistry, and beyond. More excitingly, we expect use cases to emerge that are quantum-specific, impossible on classical hardware.
This milestone isn’t just about one model. It’s a signal that the quantum AI era has begun, and that Quantinuum is leading the charge with real results, not empty hype.
Stay tuned. The revolution is only getting started.
Our team is participating in ISC High Performance 2025 (ISC 2025) from June 10-13 in Hamburg, Germany!
As quantum computing accelerates, so does the urgency to integrate its capabilities into today’s high-performance computing (HPC) and AI environments. At ISC 2025, meet the Quantinuum team to learn how the highest performing quantum systems on the market, combined with advanced software and powerful collaborations, are helping organizations take the next step in their compute strategy.
Quantinuum is leading the industry across every major vector: performance, hybrid integration, scientific innovation, global collaboration and ease of access.
- Our industry-leading quantum computer holds the record for performance with a Quantum Volume of 2²³ = 8,388,608 and the highest fidelity on a commercially available QPU available to our users every time they access our systems.
- Our systems have been validated by a #1 ranking against competitors in a recent benchmarking study by Jülich Research Centre.
- We’ve laid out a clear roadmap to reach universal, fully fault-tolerant quantum computing by the end of the decade and will launch our next-generation system, Helios, later this year.
- We are advancing real-world hybrid compute with partners such as RIKEN, NVIDIA, SoftBank, STFC Hartree Center and are pioneering applications such as our own GenQAI framework.
Exhibit Hall
From June 10–13, in Hamburg, Germany, visit us at Booth B40 in the Exhibition Hall or attend one of our technical talks to explore how our quantum technologies are pushing the boundaries of what’s possible across HPC.
Presentations & Demos
Throughout ISC, our team will present on the most important topics in HPC and quantum computing integration—from near-term hybrid use cases to hardware innovations and future roadmaps.
Multicore World Networking Event
- Monday, June 9 | 7:00pm – 9:00 PM at Hofbräu Wirtshaus Esplanade
In partnership with Multicore World, join us for a Quantinuum-sponsored Happy Hour to explore the present and future of quantum computing with Quantinuum CCO, Dr. Nash Palaniswamy, and network with our team.
Register here
H1 x CUDA-Q Demonstration
- All Week at Booth B40
We’re showcasing a live demonstration of NVIDIA’s CUDA-Q platform running on Quantinuum’s industry-leading quantum hardware. This new integration paves the way for hybrid compute solutions in optimization, AI, and chemistry.
Register for a demo
HPC Solutions Forum
- Wednesday, June 11 | 2:20 – 2:40 PM
“Enabling Scientific Discovery with Generative Quantum AI” – Presented by Maud Einhorn, Technical Account Executive at Quantinuum, discover how hybrid quantum-classical workflows are powering novel use cases in scientific discovery.
See You There!
Whether you're exploring hybrid solutions today or planning for large-scale quantum deployment tomorrow, ISC 2025 is the place to begin the conversation.
We look forward to seeing you in Hamburg!
Quantinuum has once again raised the bar—setting a record in teleportation, and advancing our leadership in the race toward universal fault-tolerant quantum computing.
Last year, we published a paper in Science demonstrating the first-ever fault-tolerant teleportation of a logical qubit. At the time, we outlined how crucial teleportation is to realize large-scale fault tolerant quantum computers. Given the high degree of system performance and capabilities required to run the protocol (e.g., multiple qubits, high-fidelity state-preparation, entangling operations, mid-circuit measurement, etc.), teleportation is recognized as an excellent measure of system maturity.
Today we’re building on last year’s breakthrough, having recently achieved a record logical teleportation fidelity of 99.82% – up from 97.5% in last year’s result. What’s more, our logical qubit teleportation fidelity now exceeds our physical qubit teleportation fidelity, passing the break-even point that establishes our H2 system as the gold standard for complex quantum operations.
This progress reflects the strength and flexibility of our Quantum Charge Coupled Device (QCCD) architecture. The native high fidelity of our QCCD architecture enables us to perform highly complex demonstrations like this that nobody else has yet to match. Further, our ability to perform conditional logic and real-time decoding was crucial for implementing the Steane error correction code used in this work, and our all-to-all connectivity was essential for performing the high-fidelity transversal gates that drove the protocol.
Teleportation schemes like this allow us to “trade space for time,” meaning that we can do quantum error correction more quickly, reducing our time to solution. Additionally, teleportation enables long-range communication during logical computation, which translates to higher connectivity in logical algorithms, improving computational power.
This demonstration underscores our ongoing commitment to reducing logical error rates, which is critical for realizing the promise of quantum computing. Quantinuum continues to lead in quantum hardware performance, algorithms, and error correction—and we’ll extend our leadership come the launch of our next generation system, Helios, in just a matter of months.