GenQAI: A New Era at the Quantum-AI Frontier
At the heart of quantum computing’s promise lies the ability to solve problems that are fundamentally out of reach for classical computers. One of the most powerful ways to unlock that promise is through a novel approach we call Generative Quantum AI, or GenQAI. A key element of this approach is the Generative Quantum Eigensolver (GQE).
GenQAI is based on a simple but powerful idea: combine the unique capabilities of quantum hardware with the flexibility and intelligence of AI. By using quantum systems to generate data, and then using AI to learn from and guide the generation of more data, we can create a powerful feedback loop that enables breakthroughs in diverse fields.
Unlike classical systems, our quantum processing unit (QPU) produces data that is extremely difficult, if not impossible, to generate classically. That gives us a unique edge: we’re not just feeding an AI more text from the internet; we’re giving it new and valuable data that can’t be obtained anywhere else.
The Search for Ground State Energy
One of the most compelling challenges in quantum chemistry and materials science is computing the properties of a molecule’s ground state. For any given molecule or material, the ground state is its lowest energy configuration. Understanding this state is essential for understanding molecular behavior and designing new drugs or materials.
The problem is that accurately computing this state for anything but the simplest systems is incredibly complicated. You cannot even do it by brute force—testing every possible state and measuring its energy—because the number of quantum states grows as a double-exponential, making this an ineffective solution. This illustrates the need for an intelligent way to search for the ground state energy and other molecular properties.
That’s where GQE comes in. GQE is a methodology that uses data from our quantum computers to train a transformer. The transformer then proposes promising trial quantum circuits; ones likely to prepare states with low energy. You can think of it as an AI-guided search engine for ground states. The novelty is in how our transformer is trained from scratch using data generated on our hardware.
Here's how it works:
- We start with a batch of trial quantum circuits, which are run on our QPU.
- Each circuit prepares a quantum state, and we measure the energy of that state with respect to the Hamiltonian for each one.
- Those measurements are then fed back into a transformer model (the same architecture behind models like GPT-2) to improve its outputs.
- The transformer generates a new distribution of circuits, biased toward ones that are more likely to find lower energy states.
- We sample a new batch from the distribution, run them on the QPU, and repeat.
- The system learns over time, narrowing in on the true ground state.
To test our system, we tackled a benchmark problem: finding the ground state energy of the hydrogen molecule (H₂). This is a problem with a known solution, which allows us to verify that our setup works as intended. As a result, our GQE system successfully found the ground state to within chemical accuracy.
To our knowledge, we’re the first to solve this problem using a combination of a QPU and a transformer, marking the beginning of a new era in computational chemistry.
The Future of Quantum Chemistry
The idea of using a generative model guided by quantum measurements can be extended to a whole class of problems—from combinatorial optimization to materials discovery, and potentially, even drug design.
By combining the power of quantum computing and AI we can unlock their unified full power. Our quantum processors can generate rich data that was previously unobtainable. Then, an AI can learn from that data. Together, they can tackle problems neither could solve alone.
This is just the beginning. We’re already looking at applying GQE to more complex molecules—ones that can’t currently be solved with existing methods, and we’re exploring how this methodology could be extended to real-world use cases. This opens many new doors in chemistry, and we are excited to see what comes next.
About Quantinuum
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.
- The Sanger Institute illustrates the value of quantum computing to genomics research
- Quantinuum supports developments in a field that promises to deliver a profound and positive societal impact
Twenty-five years ago, scientists accomplished a task likened to a biological moonshot: the sequencing of the entire human genome.
The Human Genome Project revealed a complete human blueprint comprising around 3 billion base pairs, the chemical building blocks of DNA. It led to breakthrough medical treatments, scientific discoveries, and a new understanding of the biological functions of our body.
Thanks to technological advances in the quarter-century since, what took 13 years and cost $2.7 billion then can now be done in under 12 minutes for a few hundred dollars. Improved instruments such as next-generation sequencers and a better understanding of the human genome – including the availability of a “reference genome” – have aided progress, alongside enormous advances in algorithms and computing power.
But even today, some genomic challenges remain so complex that they stretch beyond the capabilities of the most powerful classical computers operating in isolation. This has sparked a bold search for new computational paradigms, and in particular, quantum computing.
Quantum Challenge: Accepted
The Wellcome Leap Quantum for Bio (Q4Bio) challenge is pioneering this new frontier. The program funds research to develop quantum algorithms that can overcome current computational bottlenecks. It aims to test the classical boundaries of computational genetics in the next 3-5 years.
One consortium – led by the University of Oxford and supported by prestigious partners including the Wellcome Sanger Institute, the Universities of Cambridge, Melbourne, and Kyiv Academic University – is taking a leading role.
“The overall goal of the team’s project is to perform a range of genomic processing tasks for the most complex and variable genomes and sequences – a task that can go beyond the capabilities of current classical computers” – Wellcome Sanger Institute press release, July 2025
Selecting Quantinuum
Earlier this year, the Sanger Institute selected Quantinuum as a technology partner in their bid to succeed in the Q4Bio challenge.
Our flagship quantum computer, System H2, has for many years led the field of commercially available systems for qubit fidelity and consistently holds the global record for Quantum Volume, currently benchmarked at 8,388,608 (223).
In this collaboration, the scientific research team can take advantage of Quantinuum’s full stack approach to technology development, including hardware, software, and deep expertise in quantum algorithm development.
“We were honored to be selected by the Sanger Institute to partner in tackling some of the most complex challenges in genomics. By bringing the world’s highest performing quantum computers to this collaboration, we will help the team push the limits of genomics research with quantum algorithms and open new possibilities for health and medical science.” – Rajeeb Hazra, President and CEO of Quantinuum
Quantum for Biology
At the heart of this endeavor, the consortium has announced a bold central mission for the coming year: to encode and process an entire genome using a quantum computer. This achievement would be a potential world-first and provide evidence for quantum computing’s readiness for tackling real-world use cases.
Their chosen genome, the bacteriophage PhiX174, carries symbolic weight, as its sequencing earned Fred Sanger his second Nobel Prize for Chemistry in 1980. Successfully encoding this genome quantum mechanically would represent a significant milestone for both genomics and quantum computing.
Sooner than many expect, quantum computing may play an essential role in tackling genomic challenges at the very frontier of human health. The Sanger Institute and Quantinuum’s partnership reminds us that we may soon reach an important step forward in human health research – one that could change medicine and computational biology as dramatically as the original Human Genome Project did a quarter-century ago.
“Quantum computational biology has long inspired us at Quantinuum, as it has the potential to transform global health and empower people everywhere to lead longer, healthier, and more dignified lives.” – Ilyas Khan, Founder and Chief Product Officer of Quantinuum
Every year, The IEEE International Conference on Quantum Computing and Engineering – or IEEE Quantum Week – brings together engineers, scientists, researchers, students, and others to learn about advancements in quantum computing.
This year’s conference from August 31st – September 5th, is being held in Albuquerque, New Mexico, a burgeoning epicenter for quantum technology innovation and the home to our new location that will support ongoing collaborative efforts to advance the photonics technologies critical to furthering our product development.
Throughout IEEE Quantum Week, our quantum experts will be on-site to share insights on upgrades to our hardware, enhancements to our software stack, our path to error correction, and more.
Meet our team at Booth #507 and join the below sessions to discover how Quantinuum is forging the path to fault-tolerant quantum computing with our integrated full-stack.
September 2nd
Quantum Software Workshop
Quantum Software 2.1: Open Problems, New Ideas, and Paths to Scale
1:15 – 2:10pm MDT | Mesilla
We recently shared the details of our new software stack for our next-generation systems, including Helios (launching in 2025). Quantinuum’s Agustín Borgna will deliver a lighting talk to introduce Guppy, our new, open-source programming language based on Python, one of the most popular general-use programming languages for classical computing.
September 3rd
PAN08: Progress and Platforms in the Era of Reliable Quantum Computing
1:00 – 2:30pm MDT | Apache
We are entering the era of reliable quantum computing. Across the industry, quantum hardware and software innovators are enabling this transformation by creating reliable logical qubits and building integrated technology stacks that span the application layer, middleware and hardware. Attendees will hear about current and near-term developments from Microsoft, Quantinuum and Atom Computing. They will also gain insights into challenges and potential solutions from across the ecosystem, learn about Microsoft’s qubit-virtualization system, and get a peek into future developments from Quantinuum and Microsoft.
BOF03: Exploring Distributed Quantum Simulators on Exa-scale HPC Systems
3:00 – 4:30pm MDT | Apache
The core agenda of the session is dedicated to addressing key technical and collaborative challenges in this rapidly evolving field. Discussions will concentrate on innovative algorithm design tailored for HPC environments, the development of sophisticated hybrid frameworks that seamlessly combine classical and quantum computational resources, and the crucial task of establishing robust performance benchmarks on large-scale CPU/GPU HPC infrastructures.
September 4th
PAN11: Real-time Quantum Error Correction: Achievements and Challenges
1:00 – 2:30pm MDT | La Cienega
This panel will explore the current state of real-time quantum error correction, identifying key challenges and opportunities as we move toward large-scale, fault-tolerant systems. Real-time decoding is a multi-layered challenge involving algorithms, software, compilation, and computational hardware that must work in tandem to meet the speed, accuracy, and scalability demands of FTQC. We will examine how these challenges manifest for multi-logical qubit operations, and discuss steps needed to extend the decoding infrastructure from intermediate-scale systems to full-scale quantum processors.
September 5th
Keynote by NVIDIA
8:00 – 9:30am MDT | Kiva Auditorium
During his keynote talk, NVIDIA’s Head of Quantum Computing Product, Sam Stanwyck, will detail our partnership to fast-track commercially scalable quantum supercomputers. Discover how Quantinuum and NVIDIA are pushing the boundaries to deliver on the power of hybrid quantum and classical compute – from integrating NVIDIA’s CUDA-Q Platform with access to Quantinuum’s industry-leading hardware to the recently announced NVIDIA Quantum Research Center (NVAQC).
Featured Research at the IEEE Poster Session:
Visible Photonic Component Development for Trapped-Ion Quantum Computing
September 2nd from 6:30 - 8:00pm MDT | September 3rd from 9:30 - 10:00am MDT | September 4th from 11:30 - 12:30pm MDT
Authors: Elliot Lehman, Molly Krogstad, Molly P. Andersen, Sara Cambell, Kirk Cook, Bryan DeBono, Christopher Ertsgaard, Azure Hansen, Duc Nguyen, Adam Ollanik, Daniel Ouellette, Michael Plascak, Justin T. Schultz, Johanna Zultak, Nicholas Boynton, Christopher DeRose,Michael Gehl, and Nicholas Karl
Scaling Up Trapped-Ion Quantum Processors with Integrated Photonics
September 2nd from 6:30 - 8:00pm MDT and 2:30 - 3:00pm MDT | September 4th from 9:30 - 10:00am MDT
Authors: Molly Andersen, Bryan DeBono, Sara Campbell, Kirk Cook, David Gaudiosi, Christopher Ertsgaard, Azure Hansen, Todd Klein, Molly Krogstad, Elliot Lehman, Gregory MacCabe, Duc Nguyen, Nhung Nguyen, Adam Ollanik, Daniel Ouellette, Brendan Paver, Michael Plascak, Justin Schultz and Johanna Zultak
Research Collaborations with the Local Ecosystem
In a partnership that is part of a long-standing relationship with Los Alamos National Laboratory, we have been working on new methods to make quantum computing operations more efficient, and ultimately, scalable.
Learn more in our Research Paper: Classical shadows with symmetries
Our teams collaborated with Sandia National Laboratories demonstrating our leadership in benchmarking. In this paper, we implemented a technique devised by researchers at Sandia to measure errors in mid-circuit measurement and reset. Understanding these errors helps us to reduce them while helping our customers understand what to expect while using our hardware.
Learn more in our Research Paper: Measuring error rates of mid-circuit measurements
From machine learning to quantum physics, tensor networks have been quietly powering the breakthroughs that will reshape our society. Originally developed by the legendary Nobel laureate Roger Penrose, they were first used to tackle esoteric problems in physics that were previously unsolvable.
Today, tensor networks have become indispensable in a huge number of fields, including both classical and quantum computing, where they are used everywhere from quantum error correction (QEC) decoding to quantum machine learning.
In this latest paper, we teamed up with luminaries from the University of British Columbia, California Institute of Technology, University of Jyväskylä, KBR Inc, NASA, Google Quantum AI, NVIDIA, JPMorgan Chase, the University of Sherbrooke, and Terra Quantum AG to provide a comprehensive overview of the use of tensor networks in quantum computing.
Standing on the shoulders of giants
Part of what drives our leadership in quantum computing is our commitment to building the best scientific team in the world. This is precisely why we hired Dr. Reza Haghshenas, one of the world’s leading experts in tensor networks, and a co-author on the paper.
Dr. Haghshenas has been researching tensor networks for over a decade across both academia and industry. Dr. Haghshenas did postdoctoral work under Professor Garnet Chan at Caltech, a leading figure in the use of tensor networks for quantum physics and chemistry.
“Working with Dr. Garnet Chan at Caltech was a formative experience for me”, remarked Dr. Haghshenas. “While there, I contributed to the development of quantum simulation algorithms and advanced classical methods like tensor networks to help interpret and simulate many-body physics.”
Since joining Quantinuum, Dr. Haghshenas has led projects that bring tensor network methods into direct collaboration with experimental hardware teams — exploring quantum magnetism on real quantum devices and helping demonstrate early signs of quantum advantage. He also contributes to widely used simulation tools like QUIMB, helping the broader research community access these methods.
Dr. Haghshenas’ work sits in a broad and vibrant ecosystem exploring novel uses of tensor networks. Collaborations with researchers like Dr. Chan at Caltech, and NVIDIA have brought GPU-accelerated tools to bear on the forefront of applying tensor networks to quantum chemistry, quantum physics, and quantum computing.
A powerful simulation tool
Of particular interest to those of us in quantum computing, the best methods (that we know of) for simulating quantum computers with classical computers rely on tensor networks. Tensor networks provide a nice way of representing the entanglement in a quantum algorithm and how it spreads, which is crucial but generally quite difficult for classical algorithms. In fact, it’s partly tensor networks’ ability to represent entanglement that makes them so powerful for quantum simulation. Importantly, it is our in-house expertise with tensor networks that makes us confident we are indeed moving past classical capabilities.
A theory of evolution
Tensor networks are not only crucial to cutting-edge simulation techniques. At Quantinuum, we're working on understanding and implementing quantum versions of classical tensor network algorithms, from quantum matrix product states to holographic simulation methods. In doing this, we are leveraging decades of classical algorithm development to advance quantum computing.
A topic of growing interest is the role of tensor networks in QEC, particularly in a process known as decoding. QEC works by encoding information into an entangled state of multiple qubits and using syndrome measurements to detect errors. These measurements must then be decoded to identify the specific error and determine the appropriate correction. This decoding step is challenging—it must be both fast (within the qubit’s coherence time) and accurate (correctly identifying and fixing errors). Tensor networks are emerging as one of the most effective tools for tackling this task.
Looking forward (and backwards, and sideways...)
Tensor networks are more than just a powerful computational tool — they are a bridge between classical and quantum thinking. As this new paper shows, the community’s understanding of tensor networks has matured into a robust foundation for advancing quantum computing, touching everything from simulation and machine learning to error correction and circuit design.
At Quantinuum, we see this as an evolutionary step, not just in theory, but in practice. By collaborating with top minds across academia and industry, we're charting a path forward that builds on decades of classical progress while embracing the full potential of quantum mechanics. This transition is not only conceptual but algorithmic, advancing how we formulate and implement methods utilizing efficiently both classical and quantum computing. Tensor networks aren’t just helping us keep pace with classical computing; they’re helping us to transcend it.