Initiating Impact Today: Combining the World’s Most Powerful in Quantum and Classical Compute
Quantinuum and NVIDIA are reeling in a future where quantum and classical compute power unite to accelerate scientific discovery and unlock enormous commercial value.
Quantinuum and NVIDIA, world leaders in their respective sectors, are combining forces to fast-track commercially scalable quantum supercomputers, further bolstering the announcement Quantinuum made earlier this year about the exciting new potential in Generative Quantum AI.
Make no mistake about it, the global quantum race is on. With over $2 billion raised by companies in 2024 alone, and over 150 new startups in the past five years, quantum computing is no longer restricted to ‘the lab’.
The United Nations proclaimed 2025 as the International Year of Quantum Science and Technology (IYQ), and as we march toward the end of the first quarter, the old maxim that quantum computing is still a decade (or two, or three) away is no longer relevant in today’s world. Governments, commercial enterprises and scientific organizations all stand to benefit from quantum computers, led by those built by Quantinuum.
That is because, amid the flurry of headlines and social media chatter filled with aspirational statements of future ambitions shared by those in the heat of this race, we at Quantinuum continue to lead by example. We demonstrate what that future looks like today, rather than relying solely on slide deck presentations.
Our quantum computers are the most powerful systems in the world. Our H2 system, the only quantum computer that cannot be classically simulated, is years ahead of any other system being developed today. In the coming months, we’ll introduce our customers to Helios, a trillion times more powerful than H2, further extending our lead beyond where the competition is still only planning to be.
At Quantinuum, we have been convinced for years that the impact of quantum computers on the real world will happen earlier than anticipated. However, we have known that impact will be when powerful quantum computers and powerful classical systems work together.
This sort of hybrid ‘supercomputer’ has been referenced a few times in the past few months, and there is, rightly, a sense of excitement about what such an accelerated quantum supercomputer could achieve.
The Power of Hybrid Quantum and Classical Compute
In a revolutionary move on March 18th, 2025, at the GTC AI conference, NVIDIA announced the opening of a world-class accelerated quantum research center with Quantinuum selected as a key founding collaborator to work on projects with NVIDIA at the center.
With details shared in an accompanying press statement and blog post, the NVIDIA Accelerated Quantum Research Center (NVAQC) being built in Boston, Massachusetts, will integrate quantum computers with AI supercomputers to ultimately explore how to build accelerated quantum supercomputers capable of solving some of the world’s most challenging problems. The center will begin operations later this year.
As shared in Quantinuum’s accompanying statement, the center will draw on the NVIDIA CUDA-Q platform, alongside a NVIDIA GB200 NVL72 system containing 576 NVIDIA Blackwell GPUs dedicated to quantum research.
The Role of CUDA-Q in Quantum-Classical Integration
Integrating quantum and classical hardware relies on a platform that can allow researchers and developers to quickly shift context between these two disparate computing paradigms within a single application. NVIDIA CUDA-Q platform will be the entry-point for researchers to exploit the NVAQC quantum-classical integration.
In 2022, Quantinuum became the first company to bring CUDA-Q to its quantum systems, establishing a pioneering collaboration that continues to today. Users of CUDA-Q are currently offered access to Quantinuum’s System H1 QPU and emulator for 90 days.
Quantinuum’s future systems will continue to support the CUDA-Q platform. Furthermore, Quantinuum and NVIDIA are committed to evolving and improving tools for quantum classical integration to take advantage of the latest hardware features, for example, on our upcoming Helios generation.
The Gen-Q-AI Moment
A few weeks ago, we disclosed high level details about an AI system that we refer to as Generative Quantum AI, or GenQAI. We highlighted a timeline between now and the end of this year when the first commercial systems that can accelerate both existing AI and quantum computers.
At a high level, an AI system such as GenQAI will be enhanced by access to information that has not previously been accessible. Information that is generated from a quantum computer that cannot be simulated. This information and its effect can be likened to a powerful microscope that brings accuracy and detail to already powerful LLM’s, bridging the gap from today’s impressive accomplishments towards truly impactful outcomes in areas such as biology and healthcare, material discovery and optimization.
Through the integration of the most powerful in quantum and classical systems, and by enabling tighter integration of AI with quantum computing, the NVAQC will be an enabler for the realization of the accelerated quantum supercomputer needed for GenQAI products and their rapid deployment and exploitation.
Innovating our Roadmap
The NVAQC will foster the tools and innovations needed for fully fault-tolerant quantum computing and will be enabler to the roadmap Quantinuum released last year.
With each new generation of our quantum computing hardware and accompanying stack, we continue to scale compute capabilities through more powerful hardware and advanced features, accelerating the timeline for practical applications. To achieve these advances, we integrate the best CPU and GPU technologies alongside our quantum innovations. Our long-standing collaboration with NVIDIA drives these advancements forward and will be further enriched by the NVAQC.
Here are a couple of examples:
In quantum error correction, error syndromes detected by measuring "ancilla" qubits are sent to a "decoder." The decoder analyzes this information to determine if any corrections are needed. These complex algorithms must be processed quickly and with low latency, requiring advanced CPU and GPU power to calculate and apply corrections keeping logical qubits error-free. Quantinuum has been collaborating with NVIDIA on the development of customized GPU-based decoders which can be coupled with our upcoming Helios system.
In our application space, we recently announced the integration of InQuanto v4.0, the latest version of Quantinuum’s cutting edge computational chemistry platform, with NVIDIA cuQuantum SDK to enable previously inaccessible tensor-network-based methods for large-scale and high-precision quantum chemistry simulations.
Our work with NVIDIA underscores the partnership between quantum computers and classical processors to maximize the speed toward scaled quantum computers. These systems offer error-corrected qubits for operations that accelerate scientific discovery across a wide range of fields, including drug discovery and delivery, financial market applications, and essential condensed matter physics, such as high-temperature superconductivity.
We look forward to sharing details with our partners and bringing meaningful scientific discovery to generate economic growth and sustainable development for all of humankind.
About Quantinuum
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.
It is believed that unlocking answers to some of the most complex scientific and industrial problems will require the seamless integration of high-performance computing (HPC), generative AI (GenAI), and quantum computing. Toward this goal, Quantinuum, NVIDIA, and a major pharmaceutical company have successfully demonstrated the first step in a proof-of-principle framework designed to connect these three distinct computing paradigms for industrially relevant computational chemistry.
This milestone, enabled by three industry leaders and experts in their respective domains, serves as a foundational capability that could support the development of future hybrid quantum-AI workflows to help optimize industrial research and development (R&D).
The potential value is a path toward more automated, repeatable, and scalable workflows for translating chemistry problems into executable quantum programs—capabilities that could eventually make hybrid computing easier to deploy in industrial R&D.
The GenQAI Framework
The framework, termed Generative Quantum AI (GenQAI), involved a quantum computer simulating a pharmaceutical compound using programming instructions generated by an AI model, which itself was trained on quantum data that was simulated using HPC.
While the vision for GenQAI explores how future industrial simulation workflows might be optimized by training AI models using quantum data derived directly from a quantum computer, the framework currently consists of four main technical steps:
- Simulating quantum data: The process began by simulating quantum data with NVIDIA accelerated computing using NVIDIA CUDA-Q.
- Fine-tuning the AI: This simulated quantum data was used to fine-tune a pre-trained AI model from the open NVIDIA Nemotron family.
- Generating instructions: The AI model then generated quantum circuits, which are the programming instructions required for the quantum simulation.
- Validating accuracy: To validate the results, the circuits were run on Quantinuum’s Helios quantum computer using its InQuanto quantum chemistry platform.
The core novelty of this development lies within the process of the framework itself. In this proof-of-principle experiment, an AI model fine-tuned on simulated quantum data generated circuits that were successfully executed and validated on Quantinuum’s Helios system. Rather than delivering an immediate commercial advantage, this achievement establishes a credible, verifiable baseline for how HPC, AI, and quantum computing can function in tandem.
The Case Study
The validation of the framework represents an early step toward the goal of developing scalable architectures for the pharmaceutical industry.
With a shared view toward eventually scaling the framework for pharmaceutical R&D applications, the researchers simulated a pharmaceutical compound: imipramine. This anti-depressant was chosen because it serves as a model compound for drug degradation and shelf-life studies, which are standard components of the pharmaceutical R&D lifecycle.
Developing hybrid infrastructure that enterprises may adopt requires a deep, coordinated effort among domain experts. As such, this successful test highlights the value of combining the strengths of a quantum computing hardware and software leader (Quantinuum), with a hybrid-quantum classical platform (NVIDIA), and a leading enterprise end-user to build and test future computing capabilities for industrial chemistry.
Scaling the Framework
Although demonstrated on a pharmaceutical compound, the architecture could eventually inform similar molecular-simulation workflows in sectors such as energy, agriculture, advanced materials, and electronics. At this stage, it provides a reference for further testing and development.
Engage Further
Access the paper here to explore the full technical details of this demonstration and contact our team to learn more about joining Quantinuum’s enterprise partner network.
Quantinuum is pleased to announce that applications are now open for the Quantinuum SG Grand Challenge 2026, a global innovation challenge designed to bring together researchers, developers, scientists and innovators to explore practical applications of quantum computing.
Organized by Quantinuum and supported by Singapore's National Quantum Office and Aqora, the three-month program aims to foster collaboration across academia, industry and the quantum developer community while supporting the continued growth of Singapore's quantum ecosystem.
A Platform for Quantum Computing Innovation
Participants will work in teams to develop solutions across a range of challenge areas, including chemistry and molecular simulation, optimization, AI for quantum systems, quantum error correction, condensed matter and materials science, and open innovation. Throughout the program, participants will have access to mentoring, technical enablement and Quantinuum quantum computing resources.
Singapore Grand Finale
Selected finalist teams will be invited to present their work at the Grand Finale hosted in Singapore before representatives from academia, and industry. The event will celebrate innovative applications of quantum computing while providing an opportunity for participants to engage with Singapore's growing quantum community.
Join the Challenge
The Quantinuum SG Grand Challenge welcomes participants from around the world. Whether you are an experienced quantum researcher or beginning your quantum computing journey, the program offers an opportunity to collaborate, learn and contribute to the development of practical quantum applications.
Applications are now open. Spaces are limited and subject to review and approval.
- Researchers from Quantinuum, Caltech, the University of Chicago, and Harvard created a rare topologically ordered state of matter on Quantinuum's System Model H2 and used it to perform protected universal quantum gates with non-Abelian anyons.
- The work explores an alternative approach to fault tolerance by using topological properties to protect quantum information. This could reduce the need for magic state distillation, which can (in some circumstances) be resource-intensive.
- Quantinuum continues to show leadership in fault tolerance, with successful demonstrations spanning world record error rates to exotic approaches like topological computing
Quantum computing is all about putting the exotic properties of physics to work. Qubits can exist in two states at once, like the famous cat that is both alive and dead. Qubits can also be entangled, where the state of one will instantaneously affect the state of another - even when they have no way to “talk” to each other. Qubits can even be teleported, moving a quantum state from one place to another without physically moving it through space.
These features give quantum computing its power. But the ‘spooky’ nature of quantum computing doesn’t stop there: our quantum computers are potent enough to make exotic states of matter out of our qubits, and to perform calculations that would warp the mind of more traditional thinkers.
A new approach
In a recent paper published in Nature, researchers at Quantinuum teamed up with Caltech, the University of Chicago, and Harvard to create a rare ‘topologically ordered’ state of matter from our qubits.
When the qubits become ‘topologically ordered’, they become more than individual particles, now ‘related’ to each other in a specific way. This is like how hydrogen and oxygen act as individual gas particles alone, but you can put them together in a certain way so that they become water, a liquid, and an entirely different creature.
When the qubits become topologically ordered, the quantum information that they carried individually gets spread out over the whole system, which acts as a sort of protection from noise. This is like how a net makes a stronger barrier than a bunch of un-knotted ropes.
Once the researchers had topologically ordered qubits, they used the exotic particles that resulted (called non-Abelian anyons) to compute, performing error-protected gates and measurements.
To perform gates, the researchers 'braided' the anyons, which is like changing the shape of the “net”. This is something like the children’s game ‘cats cradle’. Through a sequence of changes to the “net”, the quantum computer can perform full calculations, one day helping scientists to understand the secrets hidden in the world around us.
Why go to such trouble? Well, for the love of discovery of course - but the team had an additional, specific motivation. One of the biggest challenges in building practical quantum computers is protecting them from errors while still being able to perform every operation needed for computation (this is referred to as universality).
This work takes a fresh approach to this challenge. Unlike traditional quantum error correction, the special properties of topological matter enable a universal set of fault tolerant gates without relying on expensive magic state distillation.
Why this matters
Quantum error correction is essential for large-scale quantum computing. While it protects fragile quantum information from noise by turning delicate physical qubits into robust logical qubits, it also introduces a significant constraint: not every quantum gate can be performed directly on logical qubits.
For decades, the standard solution has been to supplement error-corrected operations with magic states. These specially prepared quantum resources enable universal computation but can come at a steep cost - in many estimates of future fault-tolerant quantum computers, magic state preparation dominates both the physical qubit count and the runtime of useful algorithms.
Reducing this overhead has therefore become an important goal in quantum computing. This new approach may significantly reduce the cost by enabling the ‘topological preparation’ of magic states, eliding expensive protocols like distillation. If universal computation can be performed without large-scale magic state distillation, quantum computers could require significantly fewer physical qubits and spend much less time generating computational resources before running useful algorithms.
We will never stop exploring
While there is still considerable work ahead to understand the practical implementation and scalability of these ideas, this result expands the landscape of what's possible in quantum fault tolerance.
Of course, this impressive demonstration describes just one approach we are taking to fault tolerance at scale. We will continue to push forward with topological computing alongside more traditional approaches to quantum error correction, as well as exploring everything we can imagine in between. We are looking at a number of ways to reduce the resource cost of magic states in particular, and are making strides in multiple dimensions. With machines that are both flexible and accurate enough to do it all, who can resist?