InQuanto Integrates NVIDIA cuQuantum for Native GPU Support and Prepares for the Era of Quantum Supercomputing

With quantum progress accelerating, we introduce InQuanto v4.0 and explain how it supports customers and researchers exploring the application of AI, HPC and quantum computing – A.K.A. Quantum Supercomputing – to problems in chemistry and related fields

November 21, 2024

Chemistry plays a central role in the modern global economy, as it has for centuries. From Antoine Lavoisier to Alessandro Volta, Marie Curie to Venkatraman Ramakrishnan, pioneering chemists drove progress in fields such as combustion, electrochemistry, and biochemistry. They contributed to our mastery of critical 21st century materials such as biodegradable plastics, semiconductors, and life-saving pharmaceuticals. 

Advances in high-performance computing (HPC) and AI have brought fundamental and industrial science ever more within the scope of methods like data science and predictive analysis. In modern chemistry, it has become routine for research to be aided by computational models run in silico. Yet, due to their intrinsically quantum mechanical nature, “strongly correlated” chemical systems – those involving strongly interacting electrons or highly interdependent molecular behaviors – prove extremely hard to accurately simulate using classical computers alone. Quantum computers running quantum algorithms are designed to meet this need. Strongly correlated systems turn up in potential applications such as smart materials, high-temperature superconductors, next-generation electronic devices, batteries and fuel cells, revealing the economic potential of extending our understanding of these systems, and the motivation to apply quantum computing to computational chemistry. 

For senior business and research leaders driving value creation and scientific discovery, a critical question is how will the introduction of quantum computers affect the trajectory of computational approaches to fundamental and industrial science?

Introducing InQuanto v4.0

This is the exciting context for our announcement of InQuanto v4.0, the latest iteration of our computational chemistry platform for quantum computers. Developed over many years in close partnership with computational chemists and materials scientists, InQuanto has become an essential tool for teams using the most advanced methods for simulating molecular and material systems. InQuanto v4.0 is packed with powerful updates, including the capability to incorporate NVIDIA’s tensor network methods for large-scale classical simulations supported by graphical processing units (GPUs). 

When researching chemistry on quantum computers, we use classical HPC to perform tasks such as benchmarking, and for classical pre- and post-processing with computational chemistry methods such as density functional theory. This powerful hybrid quantum-classical combination with InQuanto accelerated our work with partners such as BMW Group, Airbus, and Honeywell. Global businesses and national governments alike are gearing up for the use of such hybrid “quantum supercomputers” to become standard practice. 

In a recent technical blog post, we explored the rapid development and deployment of InQuanto for research and enterprise users, offering insights for combining quantum and high-performance classical methods with only a few lines of code. Here, we provide a higher-level overview of the value InQuanto brings to fundamental and industrial research teams. 

InQuanto v4.0 – under the hood

InQuanto v4.0 is the most powerful version to date of our advanced quantum computational chemistry platform. It supports our users in applying quantum and classical computing methods to problems in chemistry and, increasingly, adjacent fields such as condensed matter physics.

Like previous versions of InQuanto, this one offers state-of-the-art algorithms, methods, and error handling techniques out of the box. Quantum error correction and detection have enabled rapid progress in quantum computing, such as groundbreaking demonstrations in partnership with Microsoft, in April and September 2024, of highly reliable “logical qubits”. Qubits are the core information-carrying components of a quantum computer and by forming them into an ensemble, they are more resistant to errors, allowing more complex problems to be tackled while producing accurate results. InQuanto continues to offer leading-edge quantum error detection protocols as standard and supports users to explore the potential of algorithms for fault-tolerant machines.

InQuanto v4.0 also marks the significant step of introducing native support for tensor networks using GPUs to accelerate simulations. In 2022, Quantinuum and NVIDIA teamed up on one of the quantum computing industry’s earliest quantum-classical collaborations. InQuanto v4.0 introduces classical tensor network methods via an interface with NVIDIA's cuQuantum SDK. Interfacing with cuQuantum enables the simulation of many quantum circuits via the use of GPUs for applications in chemistry that were previously inaccessible, particularly those with larger numbers of qubits.

“Hybrid quantum-classical supercomputing is accelerating quantum computational chemistry research. With Quantinuum’s InQuanto v4.0 platform and NVIDIA’s cuQuantum SDK, InQuanto users now have access to unique tensor-network-based methods, enabling large-scale and high-precision quantum chemistry simulations” - Tim Costa, Senior Director of HPC and Quantum Computing at NVIDIA

We are also responding to our users’ needs for more robust, enterprise-grade management of applications and data, by incorporating InQuanto into Quantinuum Nexus. This integration makes it far easier and more efficient to build hybrid workflows, decode and store data, and use powerful analytical methods to accelerate scientific and technical progress in critical fields in natural science.

Adding further capabilities, we recently announced our integration of InQuanto with Microsoft’s Azure Quantum Elements (AQE), allowing users to seamlessly combine AQE’s state-of-the-art HPC and AI methods with the enhanced quantum capabilities of InQuanto in a single workflow. The first end-to-end workflow using HPC, AI and quantum computing was demonstrated by Microsoft using AQE and Quantinuum Systems hardware, achieving chemical accuracy and demonstrating the advantage of logical qubits compared to physical qubits in modeling a catalytic reaction.

Where InQuanto takes us next

In the coming years, we expect to see scientific and economic progress using the powerful combination of quantum computing, HPC, and artificial intelligence. Each of these computing paradigms contributes to our ability to solve important problems. Together, their combined impact is far greater than the sum of their parts, and we recognize that these have the potential to drive valuable computational innovation in industrial use-cases that really matter, such as in energy generation, transmission and storage, and in chemical processes essential to agriculture, transport, and medicine.

Building on our recent hardware roadmap announcement, which supports scientific quantum advantage and a commercial tipping point in 2029, we are demonstrating the value of owning and building out the full quantum computing stack with a unified goal of accelerating quantum computing, integrating with HPC and AI resources where it shows promise, and using the power of the “quantum supercomputer” to make a positive difference in fundamental and industrial chemistry and related domains.

In close collaboration with our customers, we are driving towards systems capable of supporting quantum advantage and unlocking tangible and significant business value.

To access InQuanto today, including Quantinuum Systems and third-party hardware and emulators, visit: https://www.quantinuum.com/products-solutions/inquanto 

To get started with Quantinuum Nexus, which meets all your quantum computing needs across Quantinuum Systems and third-party backends, visit: https://www.quantinuum.com/products-solutions/nexus 

To find out more and access Quantinuum Systems, visit: https://www.quantinuum.com/products-solutions/quantinuum-systems 

About Quantinuum

Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents. 

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September 15, 2026
A Strategic Guide to Selecting the Right Quantum Computing Solution
For enterprise and public sector executives evaluating quantum computing investment

Quantum computing is now a strategic priority for many organizations. It's on track to help solve some of the world's biggest challenges, from drug discovery, to materials science, to optimization problems – all at a scale classical computers simply can't reach. For executives responsible for R&D, technology strategy, or innovation investment, the question is no longer whether quantum computing matters. It's how to approach it wisely.

That's a harder question than it sounds. The quantum computing market is crowded, technical, and moving fast, and most of the guidance available is written for physicists, not for the executives who actually have to make the investment decision. Vendor claims are difficult to compare, pilot programs are easy to get wrong, and the gap between "quantum is exciting" and "quantum is worth investing in this year" isn't always well explained.

Our new guide, A Strategic Guide to Selecting the Right Quantum Computing Solution, is built to close that gap.

What's Inside

The guide is designed to give business and technology leaders a clear, practical path through four essential questions:

  • Why quantum computing matters now, and why the window for early strategic advantage is open today
  • How to evaluate vendors objectively, using a structured framework rather than marketing claims
  • How to design an effective pilot, so early investment produces real, usable evidence
  • How to take your first steps with confidence, whether you're just starting to explore or ready to scale

It also includes a glossary of key terms, so readers new to the field aren't left decoding jargon before they can evaluate a single vendor.

Who Should Read It

The guide is written for CTOs, CIOs, CISOs, R&D leaders, and program directors across enterprise and public sector organizations, at any stage of quantum familiarity. Whether your organization hasn't yet started exploring quantum computing, or you already have a program underway and are looking to sharpen your evaluation process, the framework inside is designed to apply.

How to Use It

The evaluation framework at the core of the guide isn't specific to any one vendor; it's designed to be applied to any quantum computing solution you're considering, so you can make an apples-to-apples comparison based on your organization's actual needs. The guide also walks through how Quantinuum maps to that same framework, and what it looks like to work with Quantinuum as a co-development partner, should you want a concrete reference point alongside the general framework.

Start With Confidence, Not Guesswork

Quantum computing is a strategic decision, not just a technical one. The organizations that approach it with a clear framework, rather than reacting to the noise, will be the ones positioned to capture real value as the technology matures.

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September 14, 2026
Introducing the Quantum Universal Operations Performance System: QUOPS
  • QUOPS is a new, architecture-agnostic benchmark designed to measure quantum performance across physical- and logical-qubit systems, using two metrics: Q (computation size) and Ω (operations per second).
  • It addresses the limits of traditional metrics like qubit count, gate fidelity, and gate speed by measuring what a quantum system can actually execute successfully—including the effects of error correction, decoding, mitigation, compilation, and other system-level factors.
  • QUOPS aims to create a common language for the industry, helping vendors demonstrate progress, enabling buyers and governments to make more objective procurement decisions, and giving researchers a standardized way to track progress toward utility-scale, fault-tolerant quantum computing.

Quantum computing is entering a new era. As systems move from Noisy Intermediate-Scale Quantum (NISQ) toward Fault-Tolerant Application-Scale Quantum (FASQ), traditional metrics like qubit count, gate fidelity, and gate speed are no longer enough to describe what a machine can actually deliver.

Introducing QUOPS

Developed by Sandia National Laboratories, with input from Quantinuum and NVIDIA, QUOPSthe Quantum Universal Operations Performance System—is a common, architecture-agnostic benchmark for measuring quantum performance across both physical- and logical-qubit systems on the path toward quantum utility.

QUOPS can be applied to different architectures, codes, modalities, and levels of fault tolerance. QUOPS runs the same randomized workloads across different computational shapes, measures whether each workload succeeds, identifies the boundary of a system’s capability region, and reports two summary metrics:

  • Q: the largest benchmark circuit size that passes the success threshold inside a utility-motivated region. Size is defined as 2*(width)*(depth).
  • Ω: the effective operations per second at that point.

The result is a direct measure of how much computation a system can perform and how quickly it can do so. Together, these measurements provide a two-dimensional view of capability while reducing system performance to a common currency: quantum operations.

Why Quantum Computing Needs a New Metric

Component-level metrics remain essential for engineering. Qubit count, two-qubit fidelity, and gate speed can reveal control errors, crosstalk, leakage, connectivity constraints, and other system limitations. But they do not necessarily predict system-level performance.

Fault tolerance makes this gap even larger. Physical operations become logical computation with the addition of logical encoding, syndrome measurement, decoding, logical gate construction, magic-state production, routing, and control. Ultimately, this means that fault tolerance expands the relevant currencies of computation. Code distance, logical fidelity, magic-state throughput, decoding, connectivity, and space-time volume can matter far more for performance than raw qubit count or individual gate speeds.

This creates a growing challenge for buyers, governments, and researchers. As organizations move from experimentation toward larger-scale and potentially on-premise quantum systems, they need to know a simple thing:

What computation can a machine actually execute successfully?

QUOPS addresses that question by measuring the integrated system rather than inferring performance from individual components.

This is particularly important as the field considers workloads requiring roughly 10⁹–10¹² operations on thousands of qubits. Today's measured capabilities are still orders of magnitude smaller; QUOPS turns that gap into a measurable quantity.

QUOPS for Procurement

QUOPS can also provide a practical layer for quantum procurement and planning.

HPC centers need to understand when quantum computing will become useful for real workloads. Customers may have a goal of procuring a system that can, for example, run a trillion error-free operations. Today, answering these questions can require complex resource estimates that depend on hardware modality, QEC code, magic-state factories, decoding, compilation, and other architectural choices.

In both cases, QUOPS provides a simpler system-level reference point: Q describes the size of computation a machine can execute, while Ω describes its effective throughput. Furthermore, because QUOPS is architecture-neutral and includes anti-gaming provisions, it can also help buyers compare competing systems without relying solely on vendor-selected metrics or announcements.

How Quantinuum stacks up

While QUOPS is a new benchmark, it has already been measured on several vendors’ hardware. This marks an important step for our industry: we can now compare vendors directly, assessing their capabilities in a way that flattens the differences introduced by modality and architecture choices.

Figure 1. The QUOPS capability region and score for state-of-the-art processors from Quantinuum, Google, and IBM (adapted from Figure 2 of the scientific publication co-authored by Quantinuum, Sandia National Laboratories, and NVIDIA). QUOPS specifies a random circuit construction that can be built for a specified width (number of qubits) and size (number of quantum gates). A set of circuits is run at several width and size points and the average fidelity of those circuits are measured and compared to a predefined threshold. Each labeled point above represents experimental data from QUOPS circuits that passed the threshold with high confidence. The lines are filled capability limits of each machine between the points. The stars indicate the QUOPS score (Q), which is the experimental data point that passes the threshold with maximum size inside the shaded cone of width2 ≤ size ≤ width3.

Figure 2. The QUOPS score (Q) vs rate (Ω) for state-of-the-art processors from Quantinuum, Google, and IBM (adapted from Figure 2 of the QUOPS scientific publication co-authored by Quantinuum, Sandia National Laboratories, and NVIDIA). Each point is the maximum QUOPS circuit size that passes the threshold within the specified cone and rate that it was run. The dashed lines indicate the extrapolated effect of error mitigation, which attenuates the rate by including the shot overhead needed for general-purpose error mitigation. The gradient lines show the estimated runtime of a circuit at a given score and rate.

Figures 1 and 2 show how QUOPS quantifies the capability tradeoffs between different systems. Willow and Boston are superconducting systems with very fast gate speeds but limited connectivity, while Helios is a trapped-ion QCCD system with effective all-to-all connectivity but much slower gates. Willow and Boston have smaller capability regions and QUOPS scores but higher QUOPS rates; while Helios reaches larger capability regions and QUOPS scores but lower QUOPS rates. All three systems have the ability to trade speed for larger circuits with error mitigation. This is commonly assumed in the community but is nicely quantified with the QUOPS rate, which accounts for the corresponding sampling overheads of general error mitigation techniques (as shown by the dashed lines in Figure 2).

Building a New Benchmarking Ecosystem

QUOPS will not replace every quantum benchmark. The field will continue to need application-specific suites, component-level measurements, hybrid-HPC benchmarks, and independent verification.

QUOPS instead serves as a common system-level yardstick that can make roadmaps more comparable, procurement more objective, and progress easier to track.

We are calling on vendors to report QUOPS metrics (Q, Ω) and capability regions alongside existing metrics, buyers and agencies to consider QUOPS thresholds in RFPs, and researchers to contribute fault-tolerant architectures and resource estimates.

As quantum computers become fault tolerant, success will no longer be defined simply by how many qubits a machine contains or how low its error rates are.

It will be defined by the computation the machine can deliver.

QUOPS is a step toward measuring that capability—and toward giving the quantum industry a benchmark built for the era ahead.

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September 10, 2026
What Does It Take for a Quantum Computer to Actually Be “Quantum”?
  • A new experiment tests what makes a quantum computer genuinely quantum by using a simple game that demonstrates a provable advantage from quantum superposition, without relying on entanglement or assumptions about classical computational difficulty.
  • The test was demonstrated on Quantinuum’s System Model H2, where researchers ran thousands of circuits and observed results close to theoretical quantum predictions. The approach also offers an efficiently verifiable way to test for non-classical behavior.
  • The work provides a new way to think about quantum-computing verification: rather than focusing only on metrics like qubit count, we can ask whether a machine demonstrates capabilities that fundamentally distinguish quantum systems from classical ones. This validates that the computer is working as intended.

Building a quantum computer is one thing. Showing that it is genuinely using quantum mechanics is another.

A new experiment, just published in Nature Communications, takes a fresh approach to that question. Instead of relying on entanglement or the complex calculations often used to benchmark quantum computers, researchers designed a simple game (initially published in Physical Review Letters) that tests something more fundamental: quantum superposition.

Using superposition, the team constructed a game where quantum mechanics provides a provable advantage over classical approaches. Once the game was set, the team ran it on real hardware. The results showed a clear performance gap between the best possible classical system and our System Model H2 – a gap that only grew as the test became more difficult.

A game that classical computers can’t win

The game is played by a single player with access to a computer. The player receives a quantum state representing a set of numbers—for example, {0, 1, 5, 7}. Their goal is to return a number that belongs to the complement of that set: {2, 3, 4, 6}.

That sounds simple. But as the size of the sets grows, something remarkable happens.

A classical strategy needs to test many numbers to succeed. A quantum strategy, however, succeeds in one step. The authors show that the quantum strategy has a score that grows exponentially faster.

Importantly, this isn't based on an assumption that this problem is difficult for classical computers. The separation is mathematically proven. In other words, the researchers can show that the quantum advantage exists without relying on unproven assumptions from complexity theory.

Using our System Model H2, the experimenters were able to confirm the theoretically derived separation between the quantum and the classical strategy (up to the largest sizes they could fit on the quantum processor) with high confidence – showing that the violation remained close to exponential.

Testing quantum mechanics without entanglement

Many famous experiments testing quantum behavior rely on entanglement and non-locality, where multiple parties share parts of a quantum system.

This experiment is different.

There is only one player, who has access to the entire quantum system. The advantage comes from superposition—the ability of a quantum system to exist in a combination of states until it is measured.

That distinction matters because it provides another way to ask whether a quantum computer is actually behaving quantum mechanically.

The researchers turned their game into an experimental test and ran thousands of different circuits on Quantinuum's System Model H2. The scores they observed were close to the theoretical predictions for a quantum strategy.

Why verification matters

One of the challenges with existing quantum-computing demonstrations is figuring out whether the machine really produced the result it was supposed to produce.

For example, random circuit sampling can be extremely difficult to verify classically as systems become larger. That creates a tension: you want to demonstrate that a quantum computer is doing something a classical computer cannot easily reproduce, but you also need a practical way to check the result.

The complement-sampling game offers a different approach. The violation of classical performance can be efficiently verified with a classical computer.

That makes the test potentially more scalable: you don't need to reproduce the entire quantum computation on a classical computer just to determine whether the machine demonstrated non-classical behavior.

So, what makes a quantum computer “quantum”?

The deeper message of the experiment is that demonstrating a quantum computer isn't simply about having qubits.

A convincing demonstration should show that the machine is exploiting properties that genuinely distinguish quantum computation from classical computation. Here, the researchers focus on one of those defining properties—superposition—and construct a game where quantum mechanics provides a provable advantage.

This first experimental demonstration of complement sampling doesn't close every possible loophole, which is common for this sort of experiment – closing the major experimental loopholes in Bell-inequality tests took decades—a body of work that ultimately contributed to the 2022 Nobel Prize in Physics. The researchers explicitly note that the implementation relies on assumptions about how the input state is prepared, so the experimental results should be interpreted with some caution.

Still, the work provides a new way to probe the boundary between classical and quantum computation.

And that may be the most interesting part: rather than asking only “How many qubits does the machine have?”, we can ask a more meaningful question—

“What can this machine do that only a quantum system can?”

That is ultimately what it takes for a quantum computer to actually be quantum.

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