A Quantinuum-led team has built the quantum programming tools for real-time magic state distillation on a quantum computer
Researchers at Quantinuum and Microsoft’s Azure Quantum used the Quantum Intermediate Representation (QIR) to demonstrate a magic state distillation protocol for the first time on quantum hardware – a key element necessary for universal, fault-tolerant quantum computing
Building a quantum computer that offers advantages over classical computers is the goal of quantum computing groups worldwide. A competitive quantum computer must be “universal”, requiring the ability to perform all operations already possible on a classical computer, as well as new ones specific to quantum computing. Of course, that’s just the beginning – it should also be able to do this in a reasonable amount of time, to deal effectively with noise from the environment, and to perform computations to arbitrary accuracy.
This is a lot to get right, and over the years quantum computer scientists have described ways to solve these often-overlapping challenges. To deal with noise from the environment and achieve arbitrary accuracy, quantum computers need to be able to keep going even as noise accumulates on the quantum bits, or qubits, which hold the quantum information. Such fault-tolerance may be achieved using quantum error correction, where ensembles of physical qubits are encoded into logical qubits and those are used to counteract noise and perform computational operations called gates. Unfortunately, no single quantum error correction code plays well with the goal of universality because all codes lack a complete universal set of fault-tolerant gates (the technical reason for this comes down to the way quantum gates are executed between logical qubits – the native gate set on error-corrected logical qubits are known by experts as transversal gates, and they do not include all the gates needed for universal quantum computing).
The solution to this obstacle to universality is a magic state, a quantum state which provides for the missing gate when error correcting codes are used. High fidelity magic states are achieved by a process of distillation, which purifies them from other noisier magic states. It is widely recognized that magic state distillation is one of the totemic challenges on the path towards universal, fault-tolerant quantum computing. Quantinuum’s scientists, in close collaboration with a team at Microsoft, set out to demonstrate the distillation process in real-time using physical qubits on a quantum computer for the first time.
The results of this work are available in a new paper, Advances in compilation for quantum hardware -- A demonstration of magic state distillation and repeat until success protocols.
Magic state distillation
How does magic state distillation work? Imagine a factory, taking in many qubits in imperfect initial states at one end. Broadly speaking, the factory distills the imperfect states into an almost pure state with a smaller error probability, by sending them through a well-defined process over and over. In this case, the process takes in a group of five qubits. It applies a quantum error correcting code that entangles these five qubits, with four used to test whether the fifth, target qubit has been purified. If the process fails, the ensemble is discarded and the process repeats. If it succeeds, the newly distilled target qubit is kept and combined with four other successes to form a new ensemble, which then rejoins the process of continued purification. By undertaking this process many times, the purity of the magic state increases at each step, gradually moving towards the conditions required for universal, fault-tolerant quantum computing.
Despite being the subject of theoretical exploration over decades, real-time magic state distillation had never been realized on a quantum computer. In typical pioneering style, the Quantinuum and Microsoft team decided to take on this challenge. But before they could get started, they recognized that their toolset would have to be significantly sharpened up.
Creating new tools for quantum programming
At the heart of magic state distillation is a highly complex repeating process, which requires state-of-the-art protocols and control flow logic built on a best-in-class programming toolset. The research team turned to Quantum Intermediate Representation (QIR) to simplify and streamline the programming of this complex quantum computing process.
QIR is a is a quantum-specific code representation based on the popular open-sourced classical LLVM intermediate language, with the addition of structures and protocols that support the maturation and modernization of quantum computing. QIR includes elements that are essential in classical computing, but which are yet to be standardized in quantum computing, such as the humble programming loop.
Loops, which often take forms like "for...next" or "do...while," are central to programming, allowing code to repeat instructions in a stepwise manner until a condition is met. In quantum computing, this is a tough challenge because loops require control flow logic and mid-circuit measurement, which are difficult to realize in a quantum computer but have been demonstrated in Quantinuum’s System Model H1-1, Powered by Honeywell. Loops are essential for realizing magic state distillation and it’s well-understood that LLVM is great at optimizing complex control flow, including loops. This made magic state distillation a natural choice for demonstrating a valuable application of QIR and making for a great example of the use of a classical technique in a quantum context.
Result: demonstrating a magic state distillation protocol
The team used Quantinuum’s H1-1 quantum computer – benefiting from industry-leading components such as mid-circuit measurement, qubit reuse and feed-forward – to make possible the quantum looping required for a magic state distillation protocol, and becoming the first quantum computing team ever to run a real-time magic state distillation protocol on quantum hardware.
Four ways to achieve a quantum computer programmable loop
Building on this success, the team designed further experiments to assess the potential of four methods for exploring the use of a quantum protocol called a repeat-until-success (RUS) circuit to achieve a loop process. First, they hard-coded a loop directly into the extended OpenQASM 2.0, a widely used quantum assembly language, but which requires additional overhead to target advanced components on Quantinuum's very versatile H-Series quantum computer. Against this, they compared two alternative methods for coding a loop in a standard high-level programming language: controlled recursion, which was directed through both OpenQASM and through QIR; and a native for loop made possible within QIR.
The results were clear-cut: the hard-coded OpenQASM 2.0 loop performed as well as the theoretical prediction, maintaining high quality results after a number of loops, as did the natively-coded QIR for loop. The two recursive loops saw the quality of their results drop away fast as the loop limit was raised. But in a head-to-head between hard-coded OpenQASM and QIR, which converts high-level source code from many prominent and familiar languages into low-level machine code, QIR won hands-down on the basis of practicality.
Martin Roetteler, Director of Quantum Applications at Microsoft, shared: “This was a very exciting exploration of control flow logic on quantum hardware. In seeking to understand the capabilities of QIR to optimize programming structures on real hardware, we were rewarded with a clear answer, and an important demonstration of the capabilities of QIR.”
H2’s 32 qubits will power the next phase
In follow-up work, the team is now preparing to run a logical magic state protocol on the H2-1 quantum computer with its 32 high-fidelity qubits, and hopes to become the first group to successfully achieve logical magic state distillation. The features and fidelity offered by the H2 make it one of the best quantum computers currently capable of shooting for such a major milestone on the journey towards fault tolerance, while the current work demonstrates that, in QIR, the necessary control flow logic is now available to achieve it.
The paper discussed in this post was authored by Natalie C. Brown, John P. Campora III, Cassandra Granade, Bettina Heim, Stefan Wernli, Ciaran Ryan-Anderson, Dominic Lucchetti, Adam Paetznick, Martin Roetteler, Krysta Svore and Alex Chernoguzov.
About Quantinuum
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.
- Mitsui & Co. and Mitsubishi Electric demonstrated one of the world’s largest approximate Quantum Fourier Transforms (QFT) on Quantinuum Helios, scaling from prior records to 98 physical qubits.
- The collaboration also implemented a logical QFT using a QEC (Quantum Error Correction) code with up to 12 logical qubits.
- The work highlights Quantinuum’s accuracy and flexible architecture.
While there is ongoing debate around the pace of quantum computing’s development, a more grounded way to assess progress is through concrete demonstrations of foundational algorithms at meaningful scale. In this context, Mitsui & Co. and Mitsubishi Electric are taking a pragmatic view of quantum progress—focusing on how close the field is to executing core algorithmic primitives that underpin many potential industrial applications, rather than relying on abstract milestones or timelines.
In a new white paper, the industrial giants teamed up with Quantinuum to measure how close we are to running the Quantum Fourier Transform (QFT), a widely-used algorithmic primitive, at scales necessary for industrial applications. In the process, the team successfully ran one of the largest instances of the approximate QFT ever demonstrated. This achievement matters because the QFT is an essential primitive that underpins many of the quantum algorithms expected to deliver practical advantages.
You may have heard of the (classical) Fourier transform (FT), due to its ubiquity throughout modern computing. The FT is essential in everything from image analysis to data compression, with almost limitless applications in between. The quantum Fourier transform (QFT) is similar; it’s used in everything from chemistry to finance.
Because the QFT is a foundational primitive underpinning many quantum algorithms, demonstrating it at larger scales and higher fidelity is a practical way to measure quantum computing readiness. This is exactly the type of benchmarking that organizations should consider to understand where today’s systems are useful, and to see how fault-tolerant approaches are progressing. Ultimately, algorithm-level benchmarking like this is one of the most useful ways to understand not just where we are, but where we are going.
A Transformative Approach
Primitives like Fourier Transform are so widespread because they simplify problems by transforming them into something that is easier to deal with. At Quantinuum, we are very interested in transforms: not only are they crucial for industrial applications but they can also simplify algorithms, making them possible to run now instead of later. This ‘transformational’ approach extends beyond the QFT - other transforms exist, and we have even invented our own quantum-native transforms.
Using our Helios quantum computer and Guppy language, the joint team explored running the QFT on both physical qubits and on logical qubits, showing that fault tolerance is progressing quickly. Running the QFT on 98 physical qubits; the paper shows a clear progression from previous results.
Then, using the Steane code, one of the best-studied quantum error correcting codes, the team used Helios’ 98 physical qubits to form 12 logical qubits, successfully running the QFT with the mechanisms of quantum error correction interwoven into the algorithm. This marks a crucial step forward for the field.
Foundational Progress
Taken together, these results provide a more concrete lens through which to view progress in quantum computing: not as abstract projections, but as measurable advances in the execution of foundational algorithms at increasing scale. By benchmarking the Quantum Fourier Transform on both physical and logical qubits, Mitsui & Co. and Mitsubishi Electric are helping to clarify what today’s hardware can already achieve, and where fault-tolerant approaches begin to extend those limits.
More broadly, the organizations best positioned to benefit from quantum computing will be those that focus on these foundational capabilities early, and use them to build a clear, evidence-based understanding of how the technology fits into their business goals.
It is believed that unlocking answers to some of the most complex scientific and industrial problems will require the seamless integration of high-performance computing (HPC), generative AI (GenAI), and quantum computing. Toward this goal, Quantinuum, NVIDIA, and a major pharmaceutical company have successfully demonstrated the first step in a proof-of-principle framework designed to connect these three distinct computing paradigms for industrially relevant computational chemistry.
This milestone, enabled by three industry leaders and experts in their respective domains, serves as a foundational capability that could support the development of future hybrid quantum-AI workflows to help optimize industrial research and development (R&D).
The potential value is a path toward more automated, repeatable, and scalable workflows for translating chemistry problems into executable quantum programs—capabilities that could eventually make hybrid computing easier to deploy in industrial R&D.
The GenQAI Framework
The framework, termed Generative Quantum AI (GenQAI), involved a quantum computer simulating a pharmaceutical compound using programming instructions generated by an AI model, which itself was trained on quantum data that was simulated using HPC.
While the vision for GenQAI explores how future industrial simulation workflows might be optimized by training AI models using quantum data derived directly from a quantum computer, the framework currently consists of four main technical steps:
- Simulating quantum data: The process began by simulating quantum data with NVIDIA accelerated computing using NVIDIA CUDA-Q.
- Fine-tuning the AI: This simulated quantum data was used to fine-tune a pre-trained AI model from the open NVIDIA Nemotron family.
- Generating instructions: The AI model then generated quantum circuits, which are the programming instructions required for the quantum simulation.
- Validating accuracy: To validate the results, the circuits were run on Quantinuum’s Helios quantum computer using its InQuanto quantum chemistry platform.
The core novelty of this development lies within the process of the framework itself. In this proof-of-principle experiment, an AI model fine-tuned on simulated quantum data generated circuits that were successfully executed and validated on Quantinuum’s Helios system. Rather than delivering an immediate commercial advantage, this achievement establishes a credible, verifiable baseline for how HPC, AI, and quantum computing can function in tandem.
The Case Study
The validation of the framework represents an early step toward the goal of developing scalable architectures for the pharmaceutical industry.
With a shared view toward eventually scaling the framework for pharmaceutical R&D applications, the researchers simulated a pharmaceutical compound: imipramine. This anti-depressant was chosen because it serves as a model compound for drug degradation and shelf-life studies, which are standard components of the pharmaceutical R&D lifecycle.
Developing hybrid infrastructure that enterprises may adopt requires a deep, coordinated effort among domain experts. As such, this successful test highlights the value of combining the strengths of a quantum computing hardware and software leader (Quantinuum), with a hybrid-quantum classical platform (NVIDIA), and a leading enterprise end-user to build and test future computing capabilities for industrial chemistry.
Scaling the Framework
Although demonstrated on a pharmaceutical compound, the architecture could eventually inform similar molecular-simulation workflows in sectors such as energy, agriculture, advanced materials, and electronics. At this stage, it provides a reference for further testing and development.
Engage Further
Access the paper here to explore the full technical details of this demonstration and contact our team to learn more about joining Quantinuum’s enterprise partner network.
Quantinuum is pleased to announce that applications are now open for the Quantinuum SG Grand Challenge 2026, a global innovation challenge designed to bring together researchers, developers, scientists and innovators to explore practical applications of quantum computing.
Organized by Quantinuum and supported by Singapore's National Quantum Office and Aqora, the three-month program aims to foster collaboration across academia, industry and the quantum developer community while supporting the continued growth of Singapore's quantum ecosystem.
A Platform for Quantum Computing Innovation
Participants will work in teams to develop solutions across a range of challenge areas, including chemistry and molecular simulation, optimization, AI for quantum systems, quantum error correction, condensed matter and materials science, and open innovation. Throughout the program, participants will have access to mentoring, technical enablement and Quantinuum quantum computing resources.
Singapore Grand Finale
Selected finalist teams will be invited to present their work at the Grand Finale hosted in Singapore before representatives from academia, and industry. The event will celebrate innovative applications of quantum computing while providing an opportunity for participants to engage with Singapore's growing quantum community.
Join the Challenge
The Quantinuum SG Grand Challenge welcomes participants from around the world. Whether you are an experienced quantum researcher or beginning your quantum computing journey, the program offers an opportunity to collaborate, learn and contribute to the development of practical quantum applications.
Applications are now open. Spaces are limited and subject to review and approval.