KPMG and Microsoft join Quantinuum in simplifying quantum algorithm development via the cloud
The QIR Alliance, an international effort to enhance platform interoperability and enhance the work of quantum computing developers, has announced a milestone in the industry-wide effort to accelerate adoption
In 1952, facing opposition from scientists who disbelieved her thesis that computer programming could be made more useful by using English words, the mathematician and computer scientist Grace Hopper published her first paper on compilers and wrote a precursor to the modern compiler, the A-0, while working at Remington Rand.
Over subsequent decades, the principles of compilers, whose task it is to translate between high level programming languages and machine code, took shape and new methods were introduced to support their optimization. One such innovation was the intermediate representation (IR), which was introduced to manage the complexity of the compilation process, enabling compilers to represent the program without loss of information, and to be broken up into modular phases and components.
This developmental path spawned the modern computer industry, with languages that work across hardware systems, middleware, firmware, operating systems, and software applications. It has also supported the emergence of the huge numbers of small businesses and professionals who make a living collaborating to solve problems using code that depends on compilers to control the underlying computing hardware.
Now, a similar story is unfolding in quantum computing. There are efforts around the world to make it simpler for engineers and developers across many sectors to take advantage of quantum computers by translating between high level coding languages and tools, and quantum circuits — the combinations of gates that run on quantum computers to generate solutions. Many of these efforts focus on hybrid quantum-classical workflows, which allow a problem to be solved by taking advantage of the strengths of different modes of computation, accessing central processing units (CPUs), graphical processing units (GPUs) and quantum processing units (QPUs) as needed.
Microsoft is a significant contributor to this burgeoning quantum ecosystem, providing access to multiple quantum computing systems through Azure Quantum, and a founding member of the QIR Alliance, a cross-industry effort to make quantum computing source code portable across different hardware systems and modalities and to make quantum computing more useful to engineers and developers. QIR offers an interoperable specification for quantum programs, including a hardware profile designed for Quantinuum’s H-Series quantum computers, and has the capacity to support cross-compiling quantum and classical workflows, encouraging hybrid use-cases.
As one of the largest integrated quantum computing companies in the world, Quantinuum was excited to become a QIR steering member alongside partners including Nvidia, Oak Ridge National Laboratory, Quantum Circuits Inc., and Rigetti Computing. Quantinuum supports multiple open-source eco-system tools including its own family of open-source software development kits and compilers, such as TKET for general purpose quantum computation and lambeq for quantum natural language processing.
Rapid progress with KPMG and Microsoft
As founding members of QIR, Quantinuum recently worked with Microsoft Azure Quantum alongside KPMG on a project that involved Microsoft’s Q#, a stand-alone language offering a high level of abstraction and Quantinuum’s System Model H1, Powered by Honeywell. The Q# language has been designed for the specific needs of quantum computing and provides a high-level of abstraction enabling developers to seamlessly blend classical and quantum operations, significantly simplifying the design of hybrid algorithms.
KPMG’s quantum team wanted to translate an existing algorithm into Q#, and to take advantage of the unique and differentiating capabilities of Quantinuum’s H-Series, particularly qubit reuse, mid-circuit measurement and all-to-all connectivity. System Model H1 is the first generation trapped-ion based quantum computer built using the quantum charge-coupled device (QCCD) architecture. KPMG accessed the H1-1 QPU with 20 fully connected qubits. H1-1 recently achieved a Quantum Volume of 32,768, demonstrating a new high-water mark for the industry in terms of computation power as measured by quantum volume.
Q# and QIR offered an abstraction from hardware specific instructions, allowing the KPMG team, led by Michael Egan, to make best use of the H-Series and take advantage of runtime support for measurement-conditioned program flow control, and classical calculations within runtime.
Nathan Rhodes of the KPMG team wrote a tutorial about the project to demonstrate how an algorithm writer would use the KPMG code step-by-step as well as the particular features of QIR, Q# and the H-Series. It is the first time that code from a third party will be available for end users on Microsoft’s Azure portal.
Microsoft recently announced the roll-out of integrated quantum computing on Azure Quantum, an important milestone in Microsoft’s Hybrid Quantum Computing Architecture, which provides tighter integration between quantum and classical processing.
Fabrice Frachon, Principal PM Lead, Azure Quantum, described this new Azure Quantum capability as a key milestone to unlock a new generation of hybrid algorithms on the path to scaled quantum computing.
The demonstration
The team ran an algorithm designed to solve an estimation problem, a promising use case for quantum computing, with potential application in fields including traffic flow, network optimization, energy generation, storage, and distribution, and to solve other infrastructure challenges. The iterative phase estimation algorithm1 was compiled into quantum circuits from code written in a Q# environment with the QIR toolset, producing a circuit with approximately 500 gates, including 111 2-Qubit gates, running across three qubits with one reused three times, and achieving a fidelity of 0.92. This is possible because of the high gate fidelity and the low SPAM error which enables qubit reuse.
The results compare favorably with the more standard Quantum Phase Estimation version described in “Quantum computation and quantum information,” by Michael A. Nielsen and Isaac Chuang.
Quantinuum’s H1 had five capabilities that were crucial to this project:
- Qubit reuse
- Mid-circuit measurement
- Bound loop (a restriction on how many times the system will do the iterative circuit)
- Classical computation
- Nested functions
The project emphasized the importance of companies experimenting with quantum computing, so they can identify any possible IT issues early on, understanding the development environment and how quantum computing integrates with current workflows and processes.
As the global quantum ecosystem continues to advance, collaborative efforts like QIR will play a crucial role in bringing together industrial partners seeking novel solutions to challenging problems, talented developers, engineers, and researchers, and quantum hardware and software companies, which will continue to add deep scientific and engineering knowledge and expertise.
About Quantinuum
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.
- Mitsui & Co. and Mitsubishi Electric demonstrated one of the world’s largest approximate Quantum Fourier Transforms (QFT) on Quantinuum Helios, scaling from prior records to 98 physical qubits.
- The collaboration also implemented a logical QFT using a QEC (Quantum Error Correction) code with up to 12 logical qubits.
- The work highlights Quantinuum’s accuracy and flexible architecture.
While there is ongoing debate around the pace of quantum computing’s development, a more grounded way to assess progress is through concrete demonstrations of foundational algorithms at meaningful scale. In this context, Mitsui & Co. and Mitsubishi Electric are taking a pragmatic view of quantum progress—focusing on how close the field is to executing core algorithmic primitives that underpin many potential industrial applications, rather than relying on abstract milestones or timelines.
In a new white paper, the industrial giants teamed up with Quantinuum to measure how close we are to running the Quantum Fourier Transform (QFT), a widely-used algorithmic primitive, at scales necessary for industrial applications. In the process, the team successfully ran one of the largest instances of the approximate QFT ever demonstrated. This achievement matters because the QFT is an essential primitive that underpins many of the quantum algorithms expected to deliver practical advantages.
You may have heard of the (classical) Fourier transform (FT), due to its ubiquity throughout modern computing. The FT is essential in everything from image analysis to data compression, with almost limitless applications in between. The quantum Fourier transform (QFT) is similar; it’s used in everything from chemistry to finance.
Because the QFT is a foundational primitive underpinning many quantum algorithms, demonstrating it at larger scales and higher fidelity is a practical way to measure quantum computing readiness. This is exactly the type of benchmarking that organizations should consider to understand where today’s systems are useful, and to see how fault-tolerant approaches are progressing. Ultimately, algorithm-level benchmarking like this is one of the most useful ways to understand not just where we are, but where we are going.
A Transformative Approach
Primitives like Fourier Transform are so widespread because they simplify problems by transforming them into something that is easier to deal with. At Quantinuum, we are very interested in transforms: not only are they crucial for industrial applications but they can also simplify algorithms, making them possible to run now instead of later. This ‘transformational’ approach extends beyond the QFT - other transforms exist, and we have even invented our own quantum-native transforms.
Using our Helios quantum computer and Guppy language, the joint team explored running the QFT on both physical qubits and on logical qubits, showing that fault tolerance is progressing quickly. Running the QFT on 98 physical qubits; the paper shows a clear progression from previous results.
Then, using the Steane code, one of the best-studied quantum error correcting codes, the team used Helios’ 98 physical qubits to form 12 logical qubits, successfully running the QFT with the mechanisms of quantum error correction interwoven into the algorithm. This marks a crucial step forward for the field.
Foundational Progress
Taken together, these results provide a more concrete lens through which to view progress in quantum computing: not as abstract projections, but as measurable advances in the execution of foundational algorithms at increasing scale. By benchmarking the Quantum Fourier Transform on both physical and logical qubits, Mitsui & Co. and Mitsubishi Electric are helping to clarify what today’s hardware can already achieve, and where fault-tolerant approaches begin to extend those limits.
More broadly, the organizations best positioned to benefit from quantum computing will be those that focus on these foundational capabilities early, and use them to build a clear, evidence-based understanding of how the technology fits into their business goals.
It is believed that unlocking answers to some of the most complex scientific and industrial problems will require the seamless integration of high-performance computing (HPC), generative AI (GenAI), and quantum computing. Toward this goal, Quantinuum, NVIDIA, and a major pharmaceutical company have successfully demonstrated the first step in a proof-of-principle framework designed to connect these three distinct computing paradigms for industrially relevant computational chemistry.
This milestone, enabled by three industry leaders and experts in their respective domains, serves as a foundational capability that could support the development of future hybrid quantum-AI workflows to help optimize industrial research and development (R&D).
The potential value is a path toward more automated, repeatable, and scalable workflows for translating chemistry problems into executable quantum programs—capabilities that could eventually make hybrid computing easier to deploy in industrial R&D.
The GenQAI Framework
The framework, termed Generative Quantum AI (GenQAI), involved a quantum computer simulating a pharmaceutical compound using programming instructions generated by an AI model, which itself was trained on quantum data that was simulated using HPC.
While the vision for GenQAI explores how future industrial simulation workflows might be optimized by training AI models using quantum data derived directly from a quantum computer, the framework currently consists of four main technical steps:
- Simulating quantum data: The process began by simulating quantum data with NVIDIA accelerated computing using NVIDIA CUDA-Q.
- Fine-tuning the AI: This simulated quantum data was used to fine-tune a pre-trained AI model from the open NVIDIA Nemotron family.
- Generating instructions: The AI model then generated quantum circuits, which are the programming instructions required for the quantum simulation.
- Validating accuracy: To validate the results, the circuits were run on Quantinuum’s Helios quantum computer using its InQuanto quantum chemistry platform.
The core novelty of this development lies within the process of the framework itself. In this proof-of-principle experiment, an AI model fine-tuned on simulated quantum data generated circuits that were successfully executed and validated on Quantinuum’s Helios system. Rather than delivering an immediate commercial advantage, this achievement establishes a credible, verifiable baseline for how HPC, AI, and quantum computing can function in tandem.
The Case Study
The validation of the framework represents an early step toward the goal of developing scalable architectures for the pharmaceutical industry.
With a shared view toward eventually scaling the framework for pharmaceutical R&D applications, the researchers simulated a pharmaceutical compound: imipramine. This anti-depressant was chosen because it serves as a model compound for drug degradation and shelf-life studies, which are standard components of the pharmaceutical R&D lifecycle.
Developing hybrid infrastructure that enterprises may adopt requires a deep, coordinated effort among domain experts. As such, this successful test highlights the value of combining the strengths of a quantum computing hardware and software leader (Quantinuum), with a hybrid-quantum classical platform (NVIDIA), and a leading enterprise end-user to build and test future computing capabilities for industrial chemistry.
Scaling the Framework
Although demonstrated on a pharmaceutical compound, the architecture could eventually inform similar molecular-simulation workflows in sectors such as energy, agriculture, advanced materials, and electronics. At this stage, it provides a reference for further testing and development.
Engage Further
Access the paper here to explore the full technical details of this demonstration and contact our team to learn more about joining Quantinuum’s enterprise partner network.
Quantinuum is pleased to announce that applications are now open for the Quantinuum SG Grand Challenge 2026, a global innovation challenge designed to bring together researchers, developers, scientists and innovators to explore practical applications of quantum computing.
Organized by Quantinuum and supported by Singapore's National Quantum Office and Aqora, the three-month program aims to foster collaboration across academia, industry and the quantum developer community while supporting the continued growth of Singapore's quantum ecosystem.
A Platform for Quantum Computing Innovation
Participants will work in teams to develop solutions across a range of challenge areas, including chemistry and molecular simulation, optimization, AI for quantum systems, quantum error correction, condensed matter and materials science, and open innovation. Throughout the program, participants will have access to mentoring, technical enablement and Quantinuum quantum computing resources.
Singapore Grand Finale
Selected finalist teams will be invited to present their work at the Grand Finale hosted in Singapore before representatives from academia, and industry. The event will celebrate innovative applications of quantum computing while providing an opportunity for participants to engage with Singapore's growing quantum community.
Join the Challenge
The Quantinuum SG Grand Challenge welcomes participants from around the world. Whether you are an experienced quantum researcher or beginning your quantum computing journey, the program offers an opportunity to collaborate, learn and contribute to the development of practical quantum applications.
Applications are now open. Spaces are limited and subject to review and approval.